Notices

MESSAGE FROM DOE ISOTOPE PROGRAM DIRECTOR – NIDC STAFFING CHANGES

Notice #100 – November 16, 2018

Dear Isotope Stakeholder Community,

I wanted to make you aware of some staffing changes within the National Isotope Development Center (NIDC) that reports to the U.S. Department of Energy (DOE) Isotope Program. After an accomplished career with the DOE Isotope Program Dr. Wolfgang Runde, one of the Associate Directors at the NIDC, has made the decision to pursue opportunities in the private sector. While we are very sorry to see Dr. Runde move on, we are also excited for him as he takes on this new chapter in his career; yesterday was Dr. Runde's last day with the Program.

Dr. Runde joined the DOE Isotope Program in 2004 as leader of the Los Alamos National Laboratory isotope team, where he increased operational capabilities, implemented process improvements, and increased productivity. In 2007, he was selected to join the DOE Isotope Program in the Office of Nuclear Energy (NE) to coordinate the production of isotopes across the DOE complex. Upon transfer of the Program from NE to the Office of Nuclear Physics in 2009, Dr. Runde became the NIDC Associate Director for Production and Customer Relations, where he continued to coordinate radioisotope accelerator production and became the primary point of contact for accelerator-produced radioisotope customers. In 2011 and 2012, he worked directly with the management team of the DOE Isotope Program while on a detail assignment at DOE, providing essential expertise to the federal management of the program.

Dr. Runde's strong leadership over the past decade has been instrumental in boosting the production of several radioisotopes in short supply, especially production of Sr-82/Rb-82 for coronary perfusion imaging and Ge-68/Ga-68 for PET imaging. His passion for making medical radionuclides available for therapy and diagnosis of life-threatening diseases, as well as isotopes for critical energy and homeland security applications, has bolstered the DOE Isotope Program's role in these applications. In addition to his impact on commercial isotope production, he has been highly effective in advocating for research on new isotopes, production routes, and applications, and successfully balancing capabilities for R&D and commercial production. We sincerely thank Dr. Runde for his dedicated and impactful service.

Effective immediately, Ms. Karen Sikes, NIDC Manager for Marketing, will assume Dr. Runde's responsibilities regarding customer relations for accelerator-produced radioisotopes. We will work in the coming weeks to ensure a seamless transition in leadership at the NIDC. Ms. Sikes can be reached at sikeskg@ornl.gov.

Sincerely,
Jehanne Gillo

Jehanne Gillo
Director, Facilities and Project Management Division
Office of Nuclear Physics, SC-26.2
Department of Energy

Director of DOE Isotope Program

phone: (301)-903-1455
email: jehanne.gillo@science.doe.gov
IC: jehanne.gillo@doe.ic.gov

AVAILABILITY ALERT: Accelerator-produced Actinium-225 in December

Notice #99 – October 9, 2018

A new batch of accelerator-produced actinium-225 (Ac-225) will be available through the U.S. Department of Energy Isotope Program (DOE IP) in early December 2018. This alpha-emitting radionuclide and its decay product bismuth-213 (Bi-213), from an Ac-225/Bi-213 generator, have gained considerable interest within the medical community for their radioimmunotherapy applications.

The Ac-225 (half-life of 10.0 days) is produced with the DOE IP's high-energy accelerators at both Los Alamos and Brookhaven National Laboratories through the proton bombardment of natural thorium targets, and then separated and purified at Oak Ridge National Laboratory. It has a theoretical specific activity of 5.8 × 104 Ci/g at EOB and a radionuclidic purity of ≥98% (~0.12% Ac-227 at EOB).

The DOE IP has completed accelerator production campaigns for Ac-225 approximately every other month since early 2018, and the program plans to continue this schedule (depending on market demand) to ensure a reliable and abundant supply for research efforts and clinical trials. Additional batches can be produced upon demand.

Quotation requests for Ac-225 may be placed through the National Isotope Development Center's (NIDC) product catalog. For further inquiries about the availability of Ac-225, please contact Dr. Wolfgang Runde, Associate Director for Production Planning and Customer Relations, NIDC.

New NIDC Newsletter Features Ac-227 Production Ramp-Up, Argonne Facility Highlight

Notice #98 – September 28, 2018

The latest issue of our National Isotope Development Center (NIDC) Newsletter is now available! Read about the latest developments in the U.S. Department of Energy Isotope Program's product availability, university partnerships, facility improvements, staff news, and other notable activities. Highlights for this issue include:

DOE Isotope Program Posts New Funding Opportunity Announcement for Isotope Production at U.S. Universities

Notice #97 – September 27, 2018

The U.S. Department of Energy Isotope Program (DOE IP) in the Office of Nuclear Physics has posted a new Funding Opportunity Announcement (FOA) for Isotope Production at U.S. Universities (DE-FOA-0001982). This FOA is being released in furtherance of the DOE IP's newly established University Isotope Network (UIN) and can be found online at the U.S. Department of Energy's Office of Science website, or at http://science.energy.gov/np/funding-opportunities/. Eligibility for the FOA is limited to domestic institutions of higher education and domestic non-profit research institutions. National Laboratory participation is limited to a sub-awardee category. The application deadline is November 30, 2018 at 5:00 PM Eastern Standard Time.

If you have any questions, please contact Dr. Ethan Balkin, DOE IP Isotope R&D Program Manager, at Ethan.Balkin@science.doe.gov.

NIDC Job Opportunity: Communications Specialist

Notice #96 - September 18, 2018

The National Isotope Development Center (NIDC), a virtual center managed by the U.S. Department of Energy Isotope Program (DOE IP), is seeking a new Communications Specialist for its team. This staff member will oversee communications and outreach activities, spanning numerous forms of media, across the DOE IP network to increase awareness of its available isotope-related products, technical services, and R&D capabilities.

Eligible candidates must have a bachelor's degree in communications, journalism, public relations, English, or a science-related field and a minimum of 5 years of experience in communications and outreach support for a scientific or technical organization, marketing or public relations firm, or similar entity.

This position will reside in Oak Ridge, Tennessee.

Interested parties are welcome to apply here.

UPCOMING EVENT: DOE IP Fall Stakeholder Meetings

Notice #95 - September 7, 2018

The U.S. Department of Energy Isotope Program (DOE IP) has set aside Tuesday, October 30, and Wednesday, October 31, 2018, for "one-on-one" stakeholder meetings. These meetings offer a great opportunity for the isotope community to personally discuss isotope supply and demand issues with the DOE IP Director, DOE program managers, and the National Isotope Development Center (NIDC) staff.

The meetings will be held at the Hilton Washington DC/Rockville Hotel & Executive Meeting Center in Rockville, Maryland. If you would like to arrange a meeting (in person or by phone), please contact Wolfgang Runde, Associate Director for Production Planning and Customer Relations, NIDC, at runde@lanl.gov or 505-667-3350 by September 21, 2018.

AVAILABILITY ALERT: Beryllium-7 Available in September

Notice #94 - August 23, 2018

A new batch of beryllium-7 (Be-7) will be available through the U.S. Department of Energy Isotope Program (DOE IP) in early September. This gamma-emitting radionuclide (477.6 keV) is most commonly used for environmental studies such as sediment radiodating but has also recently been used by the nuclear physics community to investigate the origins of the universe.

The relatively short-lived Be-7 (t1/2= 53.3 days, decays to lithium-7) is produced in the target cooling water at Brookhaven National Laboratory's Linac Isotope Producer (BLIP) via 16O(p, spall)7Be nuclear reactions. The Be-7 product has a radionuclidic purity of >95%, with a radiochemical concentration of >1 mCi/mL in 1 MHCl.

Be-7 is not routinely produced by the DOE IP but can be made upon special request. Quotation requests for Be-7 may be placed using the National Isotope Development Center's product catalog.

For further inquiries about the availability of Be-7, please contact Dr. Wolfgang Runde, Associate Director for Production Planning and Customer Relations, NIDC.

AVAILABILITY ALERT: Accelerator-produced Actinium-225 in September

Notice #93 - August 3, 2018

A new batch of accelerator-produced actinium-225 (Ac-225) will be available through the U.S. Department of Energy Isotope Program (DOE IP) in early September. This alpha-emitting radionuclide and its decay product bismuth-213 (Bi-213, from an Ac-225/Bi-213 generator) have gained considerable interest within the medical community for its radioimmunotherapy applications.

The Ac-225 (half-life of 10.0 days) is produced with the DOE IP's high-energy accelerators at both Los Alamos and Brookhaven National Laboratories through the proton bombardment of natural thorium targets, and then separated and purified at Oak Ridge National Laboratory. It has a theoretical specific activity of 5.8 × 104Ci/g at EOB and a radionuclidic purity of ≥98% (~0.12% Ac-227 at EOB).

The DOE IP has completed accelerator production campaigns for Ac-225 every other month since early 2018, and the program plans to continue the bi-monthly schedule (depending on market demand) to ensure a reliable and abundant supply for research efforts and clinical trials. Additional batches can be produced upon demand.

Quotation requests for Ac-225 may be placed using the National Isotope Development Center's product catalog. For further inquiries about the availability of Ac-225, please contact Dr. Wolfgang Runde, Associate Director for Production Planning and Customer Relations, NIDC.

DEADLINE EXTENDED: Federal Position in the DOE Isotope Program

Notice #92 - July 18, 2018

The U.S. Department of Energy Isotope Program (DOE IP) has extended the closing date to July 23, 2018, for the Program Manager for Isotope Facilities job posting. Interested and serious individuals are invited to apply for this permanent federal position at:

The DOE IP Program Manager for Isotope Facilities will focus on the operations of Isotope Facilities within the scope of the program, including their needed resources and productivity. This individual will be responsible for the performance of these facilities, strategic planning associated with the facilities and the development of new production capabilities within the program. This position would be located at DOE HQ in Germantown, Maryland.

JUST POSTED: FEDERAL POSITION IN THE DOE ISOTOPE PROGRAM

Notice #91 - July 10, 2018

The U.S. Department of Energy (DOE) Isotope Program is seeking a new Program Manager for Isotope Facilities. Interested and serious individuals are invited to apply for this permanent federal position at:

The Program Manager for Isotope Facilities will focus on the operations of Isotope Facilities within the scope of the program, including their needed resources and productivity. This individual will be responsible for the performance of these facilities, strategic planning associated with the facilities, and the development of new production capabilities within the program. The position is located at the DOE Headquarters in Germantown, Maryland.

This posting will remain open through July 16, 2018.

UPCOMING ANNOUNCEMENT FOR FEDERAL POSITION IN THE DOE ISOTOPE PROGRAM

Notice #90 - June 29, 2018

The U.S. Department of Energy (DOE) Isotope Program is advertising for a new permanent federal program manager, the Program Manager for Isotope Facilities. The position will be advertised on July 9that www.usajobs.govand will be open ONLY FOR SEVEN DAYS. Interested and serious individuals are invited to apply. The position is located at DOE HQ in Germantown, Maryland. This person would be reporting directly to me and would be a member of the federal team managing the DOE Isotope Program. The previous Program Manager for this portfolio, Ethan Balkin, has assumed the responsibilities for Program Manager for Isotope R&D, which was vacated when Dr. Dennis Phillips retired.

The Program Manager for Isotope Facilities will focus on the operations of Isotope Facilities within the scope of the isotope program, including their needed resources and productivity. This Program Manager will be responsible for the performance of these facilities, strategic planning associated with the facilities and the development of new production capabilities within the program.

Serious inquiries may contact me at the information below.
----------------------------------------------------------------
Dr. Jehanne Gillo
Director, Facilities and Project Management Division
Office of Nuclear Physics, SC 26.2
Department of Energy
Director of DOE Isotope Program
Phone: (301)-903-1455
Email: jehanne.gillo@science.doe.gov
IC: jehanne.gillo@doe.ic.gov
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Feature Article Chronicles the DOE Isotope Program's Pursuit to Enhance Ac-225 Supply

Notice #89 - June 22, 2018

Actinium-225 (Ac-225) is a promising medical radioisotope well known for its cancer-fighting abilities. Limited production capabilities, however, have curbed its potential as a widespread therapy option. A new U.S. Department of Energy (DOE) feature article entitled, "The Journey of Actinium-225: How Scientists Discovered a New Way to Produce a Rare Medical Radioisotope," details how scientists at Brookhaven, Los Alamos, and Oak Ridge National Laboratories are pursuing a new accelerator-based production route that could dramatically increase future supply.

Engage with Us at SNMMI 2018!

Notice #88 - June 11, 2018

The U.S. Department of Energy Isotope Program (DOE IP) wants to hear from you at the Society of Nuclear Medicine and Molecular Imaging's (SNMMI) 2018 Annual Meeting later this month in Philadelphia, PA. We invite you to join us at our DOE IP Users Meetingon Monday, June 25, from 7:00 a.m. to 8:00 a.m. An invitation to this open event from Dr. Jehanne Gillo, DOE IP Director, and Dr. Marc Garland, National Isotope Development Center Director, is attached.

Also, please visit us at Booth #251 to speak with our staff about your isotope needs and to find informational material on our latest products and services, R&D initiatives, and more.

We look forward to seeing you in Philly!

DOE Isotope Program, Bayer Finalize Major Contract for Supply of Ac-227

Notice #87 - June 1, 2018

The U.S. Department of Energy Isotope Program has agreed to terms with Bayer on a 10-year supply contract for actinium-227 (Ac-227) to support the company's anticipated market growth of Xofigo®, a drug proven to prolong survival and improve the quality of life for patients with prostate cancer that has metastasized to the skeleton. The Ac-227 is produced at and shipped from Oak Ridge National Laboratory (ORNL). Upon arrival in Norway, Bayer will periodically extract radium-223, the active ingredient in Xofigo®, from the decaying Ac-227 and ship it to treatment facilities in 52 countries where it is now approved.

See full press releases from ORNL and Bayer.

Major Milestones in Enriched Stable and Alpha-Emitting Isotope Production Highlighted in New NIDC Newsletter

Notice #86 - May 24, 2018

The latest issue of our National Isotope Development Center (NIDC) Newsletter is now available! Read about the latest developments in the U.S. Department of Energy's (DOE) isotope production, university partnerships, facility improvements, staff news, and other notable center activities. Highlights for this issue include:

ORNL Team Recognized for "Extraordinary Effort" in Ru-96 Production Campaign

Notice #85 - May 16, 2018

A team of 11 research staff at the Oak Ridge National Laboratory (ORNL) has been commended by the U.S. Department of Energy (DOE) for their instrumental roles in the campaign to produce the enriched stable isotope ruthenium-96 (Ru-96), last produced in the United States more than 40 years ago. Presented on behalf of Dr. Stephen Binkley, Deputy Director for Science Programs in the Office of Science, these awards express the Department's appreciation for the tremendous effort that this activity demanded, resulting in a significant capability for the Nation and enabling critical nuclear physics research to move forward.

The newly enriched Ru-96 provided scientists at Brookhaven National Laboratory with a sufficient amount to study the properties of quark-gluon plasma, a new form of matter discovered at the lab's Relativistic Heavy Ion Collider that has not existed since the infant universe.

The Ru-96 production campaign marked the inaugural effort of the newly commissioned Enriched Stable Isotope Prototype Plant (ESIPP) at ORNL, sponsored by the DOE Isotope Program.

Please join us in congratulating the team on this significant achievement!


ORNL team receives DOE appreciation awards for extraordinary effort in Ru-96 production campaign (Back row, from left: Brian Sparks, Andrew Barclay, Clint Ausmus, Adam Stevenson, and Mike Zach; front row, from left: Kevin Hart, Brian Egle, Derek Byrd, Gerald Mills, Alan Tatum, and David Dean) (Image courtesy of ORNL)

BNL's Srivastava Presented with 2018 Seaborg Award for Nuclear Chemistry

Notice #84 - May 7, 2018

Suresh Srivastava, a Senior Medical Scientist Emeritus and research advisor in the Collider-Accelerator Department and Medical Isotope Research & Production Program at Brookhaven National Laboratory (BNL), is this year's recipient of the Glenn T. Seaborg Award. He recently accepted the award during the American Chemical Society's (ACS) Spring 2018 National Meeting & Exposition in New Orleans, Louisiana.

The prestigious award, sponsored by the ACS Division of Nuclear Chemistry and Technology (NUCL), has been presented annually since 1955, recognizing individuals who have made outstanding contributions to the advancement of the science or application of nuclear chemistry and radiochemistry.

Since first arriving at BNL in 1965, Suresh has played a vital role in the conception, development, and market transition of numerous radionuclides used in nuclear medicine. His peers view him as a pioneer for his achievements in the field of theranostics-radiopharmaceuticals capable of both diagnosing and treating cancer and cardiovascular disease, among other serious illnesses. In 2009, Suresh co-founded the World Association of Radiopharmaceutical and Molecular Therapy (WARMTH) to promote the use of such radionuclide molecular therapy and recently concluded a two-year term as the association's president. He holds a B.S. in chemistry and biology, an M.S. in organic chemistry from Agra University, and a Ph.D. in nuclear and biological chemistry from University of Allahabad.

Please join us in congratulating Suresh on this significant achievement!

DOE IP-Supported Travel Bursaries for Students and Postdoctoral Trainees - UPDATED GUIDANCE

Notice #83 - April 26, 2018

Subject to the availability of funds, the U.S. Department of Energy Isotope Program (DOE IP) considers a limited number of proposals to offer travel bursaries for students and postdoctoral trainees to attend domestic and international conferences, meetings, or workshops. All proposals are competitively reviewed, and selections are made based on numerous criteria that align with the DOE IP mission.

This notice is to distribute the guidance from the DOE IP on travel bursaries, which can be found in the attached file. Specifically, it provides guidance for both proposal preparation and post-award actions (i.e. selection of qualified students and postdocs).

Please direct any questions to Dr. Ethan Balkin, DOE Isotope R&D Program Manager.

SAVE THE DATE: DOE Isotope Program User Group Meetings

Notice #82 - April 23, 2018

The DOE Isotope Program (DOE IP) will host three user group meetings during the upcoming Annual Society of Nuclear Medicine and Molecular Imaging (SNMMI) conference in Philadelphia, PA.

These meetings are being organized by the DOE IP to encourage free discussion and collaboration by users of specific isotopes as well as to provide information on the broader DOE IP portfolio. Details on each meeting are provided below:

All three DOE-hosted meetings will be held in Rooms 305-306 (combined) at the Philadelphia Marriott Downtown.

In addition, the DOE IP will be providing input to the following sessions:

Please contact Dr. Wolfgang Rundewith any questions. We hope to see you there!

DOE Isotope Program in the Office of Nuclear Physics Posts New Funding Opportunity Announcement for Research, Development and Training in Isotope Production

Notice #81 - April 3, 2018

The U.S. Department of Energy's Isotope Program has posted a new Funding Opportunity Announcement (FOA) for Research, Development and Training in Isotope Production (DE-FOA-0001896). This FOA can be found online at the U.S. Department of Energy's Office of Science website, or at http://science.energy.gov/np/funding-opportunities/. Eligibility for the FOA is limited to domestic institutions of higher education, domestic non-profit research institutions, and national laboratories. The application deadline is June 15, 2018, by 5:00 P.M. Eastern Standard Time.

If you have any questions please email Dr. Ethan Balkin at Ethan.Balkin@science.doe.gov.

OPEN POSITION OPPORTUNITY IN THE DOE ISOTOPE PROGRAM - HEADQUARTERS (GERMANTOWN, MD)

Notice #80 - March 22, 2018

A MESSAGE FROM THE DIRECTOR OF THE U.S. DEPARTMENT OF ENERGY ISOTOPE PROGRAM

Hello everyone,

I would like to announce that the Department of Energy (DOE) Program Manager for Isotope Facilities, Dr. Ethan Balkin, has expressed interest in assuming the responsibilities of Program Manager for Isotope R&D. This was the position vacated by Dr. Dennis Phillips when he retired last year. So please welcome Dr. Balkin as the new federal Program Manager for Isotope R&D.

In addition, I'd like to give the community advance notification of a position that will be advertised in the very near future (hopefully in the next few weeks) within the DOE Isotope Program. This permanent federal position-Program Manager for Isotope Facilities-will be located at DOE's Germantown, Maryland, headquarters site. This individual would report directly to me and would join the team in the DOE Office of Science for Nuclear Physics. You must be a U.S. citizen to apply.

This is a very important position within our team. This individual is responsible for routine isotope production at the reactors and accelerator facilities across the DOE national laboratory complex, as well as the consideration of the feasibility of new isotope production, and maintenance/upgrade of the isotope production facilities. It is a critical role in the strategic planning for the DOE Isotope Program. I urge you to give this position some thought and to bring qualified candidates to my attention at jehanne.gillo@science.doe.gov. Feel free to contact me for more details. We look forward to receiving applications for the Program Manager for Isotope Facilities in the very near future.

With best regards,

Dr. Jehanne Gillo
Director, Facilities and Project Management Division
Office of Nuclear Physics, SC-26.2
Department of Energy
Director of DOE Isotope Program
phone: (301)-903-1455
email: jehanne.gillo@science.doe.gov
IC: jehanne.gillo@doe.ic.gov

DOE Produces First Newly Enriched Stable Isotope in Nearly Two Decades

Notice #79 - March 14, 2018

The U.S. Department of Energy's Isotope Program (DOE IP) recently provided more than 500 mg of highly enriched ruthenium-96 (Ru-96), most of which was newly produced at Oak Ridge National Laboratory's Enriched Stable Isotope Pilot Plant (ESIPP). This marks the first production of a newly enriched stable isotope by the DOE IP in nearly 20 years. In addition, this milestone successfully fulfills a recommendation by the Isotope Subcommittee of the Nuclear Science Advisory Committee for the DOE IP to re-establish a domestic stable isotope enrichment capability.

The Ru-96 will be used at Brookhaven National Laboratory for experiments at its Relativistic Heavy Ion Collider (RHIC). Due to insufficient quantities of this rare isotope in DOE's inventory or availability from other sources worldwide, a new production campaign at ESIPP was initiated. The RHIC experiment required enrichment exceeding 92 atom % with high chemical purity (>98%). Ruthenium-96 in naturally occurring Ru metal is only 5.5 atom %.

With the Ru-96, the RHIC nuclear physics experiment will study the dynamics of the quark gluon plasma created in ion collisions in response to electromagnetic fields generated by the colliding ions; the quark gluon plasma is a new form of matter discovered at RHIC and has not existed since the infant universe. The availability of the Ru-96 makes this research viable.

Production of Ru-96 will continue at ESIPP through 2018, then will be followed with production of other stable isotopes approaching critical supply levels. Parties interested in procuring Ru-96 or other stable isotopes can request a quote through the National Isotope Development Center's product catalog. For additional inquiries on Ru-96 availability, please contact the Isotope Business Office.

PNNL Researchers Automate Column-Based Purification of 89Zr

Notice #78 - March 1, 2018

An automated purification of zirconium-89 (89Zr) from a yttrium (Y) target has been developed by researchers at the Pacific Northwest National Laboratory (PNNL), in collaboration with the University of Washington Department of Radiology, and is detailed in the February 2018 issue of Applied Radiation and Isotopes.

A positron emitter with a relatively long half-life (78.4 h), 89Zr is a promising radionuclide for immuno-positron emission tomography (immunoPET) applications, wherein 89Zr-labeled antibodies, antibody fragments, aptamers, etc. are tracked and quantified in vivo. The half-life of 89Zr is sufficiently long to assure time for these labeled proteins to reach tumor sites.

The most common technique for producing 89Zr is by bombarding natural Y targets in a cyclotron. The resulting 89Zr is then purified from the dissolved Y targets. Most commonly, the 89Zr purification is performed using a hydroxamate resin column, wherein 89Zr is loaded onto the column from the dissolved Y target in hydrochloric acid (HCl), the column is washed with the acid to remove Y, and then the isolated 89Zr is eluted from the column using 1 M oxalic acid (H2C2O4).

In this paper, the research team describes a simple, automated fluidic system prototype for the purification of 89Zr that provides near-real time monitoring of column effluents. In addition, the team demonstrated that a lower concentration of 89Zr eluent can be used with no decrease in 89Zr product yield. An advantage of lower isotope product solution strength is that proportionally less buffering salts are required to be added prior to protein labeling, and less additives mean a lowered opportunity for contamination of the isotope product with metals that compete for labeling sites. The authors performed titrations on several buffered 89Zr product fractions using deferoxamine to assess product purity and demonstrated purity levels on par with previously reported values. Additional findings are detailed in the full manuscript.

This work was funded by the U.S. Department of Energy Isotope Program. If interested in licensing 89Zr purification-related technology, please contact Eric Lund, PNNL Technology Deployment Manager, at (509) 375-3764.

NIDC Discusses Latest Efforts to Enhance DOE Isotope Portfolio in New Quarterly Newsletter

Notice #76 - January 10, 2018

The latest issue of our National Isotope Development Center (NIDC) Newsletteris now available! Read about the latest developments in the U.S. Department of Energy's (DOE) isotope production, university partnerships, facility improvements, staff news, and more. Highlights for this issue include:

ISOTOPE AVAILABLITY ALERT: Lutetium-177 Produced at MURR Available through the DOE Isotope Program

Notice #75 - September 29, 2017

The U.S. Department of Energy Isotope Program is pleased to announce the availability of lutetium-177 (Lu-177) for distribution through our partnership with the University of Missouri Research Reactor Center (MURR). Lu-177 is a radioisotope commonly used for research in cancer treatment and has a half-live of 6.65 days. The product, Lu-177 chloride solution (0.05 MHCl), has a specific activity of ≥20 Ci/mg and a radioisotopic purity of ≥99% at the time of production. There is a minimum charge per order of 25 mCi (less activity can be ordered, but 25 mCi is the minimum charge).

For applications requiring a higher specific activity, DOE also takes special requests for ≥50 Ci/mg Lu-177 (at the time of production) produced at Oak Ridge National Laboratory's High Flux Isotope Reactor (HFIR). Production and delivery times will be dependent on HFIR's predetermined production cycles.

Quotation requests for Lu-177 may be placed using the National Isotope Development Center's Online Catalog of Isotope Products.

Heavy Water (D2O) Available from the DOE Isotope Program

Notice #74 - September 11, 2017

The U.S. Department of Energy's (DOE) Isotope Program is pleased to announce the availability of heavy water (D2O) for research purposes. The general specifications of the material are given in the table below. Additional analytical results are available upon request.

Heavy Water (D2O)
Parameter Specification Units
Isotopic Concentration ≥99.80 mol % D2O
Conductivity (at 25°C) ≤3 µS/cm
pH 6 to 7 pH
Turbidity ≤ 2 NTU
Tritium < 2 µCi/kg

The heavy water is packaged in polypropylene-coated, stainless steel kegs, each with a capacity of 50 L and measuring approximately 41 cm in diameter × 54 cm height (see figure). Full kegs have a gross weight of approximately 63 kg, which includes 50 kg of heavy water. To ensure product quality, purchases may only be made in full keg quantities.

Please direct any questions or requests for additional information to Mitch Ferren, Associate Director for Business Operations, National Isotope Development Center, at ferrendm@ornl.govor 865-574-6602.

For quotes, submit a request on the NIDC website.

Isotope Program Stakeholder Meetings

Notice #73 - August 17, 2017

The Department of Energy's Isotope Program (DOE IP) has set aside two days, Tuesday, November 7 and Wednesday, November 8, 2017, for "one-on-one" meetings with interested commercial customers to discuss isotope supply and demand issues. The meetings will be held at the DOE offices in Germantown, Maryland, or at a nearby location. The meetings provide an opportunity for the isotope community to discuss issues with the director and managers of the DOE IP.

If you would like to arrange a meeting, please contact Wolfgang Runde, NIDC Associate Director, at runde@lanl.gov or 505-231-0826 by September 29, 2017.

DOE Isotope Program Translates Research to Applications in New Video

NIDC Notice #72 - August 14, 2017

Unveiled at the Society of Nuclear Medicine and Molecular Imaging Annual Meeting in June, a new six-minute video showcasing the U.S. Department of Energy Isotope Program gives viewers a behind-the-scenes look at the production of isotopes critical to everyday applications, particularly in the medical arena. For instance, researchers across our national laboratory network explain how continuously improving production techniques for radioisotopes like actinium-225, astatine-211, lead-212, and copper-67 directly impacts the accuracy and efficacy of targeted cancer therapies. The video also demonstrates how integrating universities into DOE's network helps to broaden production capabilities and, therefore, more efficiently fulfill end-user requests.

ISOTOPE AVAILABLITY ALERT: Uranium-234 Back in Inventory

NIDC Notice #71 - August 3, 2017

Following several years of constrained supply, the U.S. Department of Energy Isotope Program has replenished its inventory and is accepting new orders for the radioisotope uranium-234 (U-234), which is most commonly used to prolong the life of flux monitors for nuclear power plants. The available U-234 is recovered via chemical ion-exchange from substantial amounts of aged plutonium-238 housed at the Oak Ridge National Laboratory. The U-234 (half-life of 246,000 years) has a theoretical specific activity of 6.23 mCi/g and a radioisotopic purity of >99%. It is sold in oxide (U3O8) form.

Quotation requests for U-234 may be placed using the National Isotope Development Center's Online Catalog of Isotope Products.

Private Sector Survey Form

NIDC Notice #70 - July 26, 2017

PLEASE RESPOND DIRECTLY TO WOLFGANG RUNDE. HIS CONTACT INFORMATION HAS BEEN PROVIDED BELOW.

This announcement is intended to seek information from private companies on their potential isotope needs for the next five years and is not a Request for Proposal (RFP) or an Invitation for Bid (IFB), nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

The mission of the Isotope Development and Production for Research and Applications (IDPRA) Program within the Office of Nuclear Physics of the Department of Energy's Office of Science is to develop, produce and distribute stable and radioactive isotope products that are in short supply and of critical importance to the Nation. The IDPRA Program manages the National Isotope Development Center (NIDC), which coordinates isotope production across Department of Energy (DOE) facilities and, for some isotopes, non-Federal facilities as well. This synopsis is to notify the public that the NIDC, on behalf of the IDPRA, seeks information from the community on anticipated needs of isotope products and potential supply shortages in the next five years. The IDPRA seeks this information to better understand the demand for isotopes used in research or commercial applications, including devices such as detectors and calibration sources and gauges that contain isotopes. Business and research entities should identify isotopes that are needed but are in short supply, in which they encounter uncertain supply issues, and/or that they expect an increase in demand that cannot be met by the current supply. The IDPRA, working with the NIDC, will use this information for strategic planning to enhance the reliability and availability of isotopes to the community. The information provided in this request form will assist the IDPRA in optimizing production plans in the upcoming fiscal years and in strategically planning the future production of isotopes, gauging future demand, and evaluating and investing in the needs for isotope production technology development.

The NIDC is requesting that companies complete and submit the attached survey form to runde@lanl.gov by August 18, 2017. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2018-2022. All information submitted is considered highly business-sensitive and will not be shared or discussed outside the IDPRA. For workshop reports and additional information on the IDPRA program, please visit our website.

Excluded from this request are helium-3 and molybdenum-99.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

DOE Isotope Program Bids Farewell to Exemplary Scientist

Notice #69 - July 20, 2017

After thirty-six years of outstanding leadership and exceptional performance as a Senior Scientist and program manager at Brookhaven National Laboratory (BNL), Dr. Leonard Mausner is retiring on July 28.

The Brookhaven Linac Isotope Producer (BLIP) name has become synonymous with Dr. Mausner's, who has played a critical role in its operation in support of the U.S. Department of Energy Isotope Program. His conception and implementation of several major facility upgrades helped boost availability of isotopes used in high-priority research and medical applications, and his techniques have since been applied at facilities worldwide, bolstering BNL's reputation in the isotope arena. He has also contributed to the development of several medical radionuclides used for therapy and diagnosis of life-threatening diseases. Among these are actinium-225 (cancer therapy), xenon-127 (lung imaging), tin-117m (bone pain palliation), and strontium-82/rubidium-82 (coronary perfusion imaging).

An already remarkable career was topped off last month when Dr. Mausner was presented with a Career Appreciation plaque by the DOE Office of Science at the Society of Nuclear Medicine and Molecular Imaging's Annual Meeting. He was also recently announced as a BNL 2017 Science and Technology Award recipient.

Aside from his research accolades, Dr. Mausner has been a strong advocate for the American Chemical Society's Summer School in Nuclear and Radiochemistry (NCSS), championing the program at BNL. His involvement in NCSS will continue into his retirement.

We sincerely thank Dr. Mausner for his dedicated and impactful service, and wish him the best in all his future endeavors.

Partnership for University Reactor-Based Isotope Production of Selenium-75 Finalized

Notice #68 - July 12, 2017

The U.S. Department of Energy's (DOE) Isotope Program is pleased to announce a new partnership with the University of Missouri that further strengthens the nation's isotope portfolio. Finalized in May 2017, the partnership enables the University of Missouri Research Reactor Center (MURR), located in Columbia, Missouri, to supply the biological tracer and research isotope selenium-75 (Se-75) through the National Isotope Development Center's (NIDC) Isotope Business Office. The high purity, high specific activity Se-75 will be routinely processed and dispensed from inventory at the MURR.

This partnership marks the second agreement (first reactor-based production agreement) within a network of university facilities that works with the DOE Isotope Program to promote production and availability of high priority isotopes, as recommended in the NSAC-I 2015 Long-Range Plan. Consideration of additional university sites to the network is underway.

Quotation requests for Se-75 may be placed using the NIDC's Online Catalog of Isotope Products. For further information, please contact Dr. Wolfgang Runde (runde@lanl.gov), Associate Director for Production Planning and Customer Relations, NIDC.

Isotopes Routinely Available: Radium-223 and Thorium-227

Notice #67 - June 1, 2017

The U.S. Department of Energy's Isotope Program seeks to remind the user community of the routine availability of radium-223 (Ra-223: t1/2= 11.4 days) and thorium-227 (Th-227: t1/2= 18.7 days). These alpha-emitters are obtained from Ac-227 cows to produce very high purity products. Isotopes milked from the cows are separated and purified at Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL).

The cows currently have the capability of producing hundreds of mCi of Ra-223 and Th-227 per month, allowing for the capability to support basic science and pre-clinical research. Production at two National Laboratories provides distribution of highly pure Ra-223 and Th-227 across the Nation on a regular basis and addresses a recommendation in the Nuclear Science Advisory Subcommittee on Isotopes (NSAC-I 2015) Long Range Plan (http://science.energy.gov/~/media/np/nsac/pdf/docs/2015/2015_NSACI_Report_to_NSAC_Final.pdf).

Quotation requests for Ra-223 and Th-227 may be placed using the National Isotope Development Center's (NIDC) online catalog (https://www.isotopes.gov/catalog/). If you are interested in further information, please contact Dr. Wolfgang Runde at runde@lanl.gov, Associate Director for Production Planning and Customer Relations, NIDC.

Attend the DOE Isotope Program User Meetings

Notice #66 - May 14, 2017

The DOE Isotope Program (DOE IP) is pleased to announce that three users group meetings have been scheduled during the upcoming Annual Society of Nuclear Medicine and Molecular Imaging conference in Denver, Colorado. The DOE Users Group Meeting will provide a general update on DOE IP activities and initiatives and an opportunity for the user community to ask questions and provide feedback. Topics to be covered include alpha emitters (e.g. Ac-225), theranostic isotopes (e.g. Cu-67), a programmatic update, and a tribute to Leonard Mausner who will be retiring from Brookhaven National Laboratory. Two other meetings are scheduled to facilitate free discussion and collaboration by users of specific isotopes (At-211 and Pb-212). Dates, times, and meeting locations can be found below. Please contact Dr. Wolfgang Runde with any questions (runde@lanl.gov). We hope to see you there!

DOE Users Group Meeting
Date: Tuesday, 6/13/2017
Time: 7:00 AM to 8:00 AM
Location: Colorado Convention Center, Meeting Room 106

Pb-212 Users Group
Date: Tuesday, 6/13/2017
Time: 3:00 PM to 4:00 PM
Location: Hyatt Regency Denver at the Colorado Convention Center, Meeting Room Agate A

At-211 Users Group
Date: Tuesday, 6/13/2017
Time: 4:00 PM to 5:00 PM
Location: Hyatt Regency Denver at the Colorado Convention Center, Meeting Room Agate A

DOE Isotope Program Announces the Availability of Additional Isotopes

Notice #65 - May 18, 2017

The DOE Isotope Program has initiated several efforts to re-establish the production of some selected radioisotopes that have been requested by stakeholders and the user community. These isotopes are in short supply or have been unavailable worldwide. For example, the DOE Isotope Program has developed production of Si-32, Ti-44, Cu-67, Cd-109, Ba-133, and Ac-225. Among these, Si-32, Al-26, and Ti-44 have been recently produced and are currently available for sale. Production of the other isotopes will be scheduled as needed. The DOE Isotope Program will engage in routine production of short-lived isotopes, e.g. Cu-67, if there is sufficient demand.

Silicon-32 (Si-32)is now available
To request a quotation for Si-32, please visit our website at isotopes.gov.

Titanium-44 (Ti-44)is now available
To request a quotation for Ti-44, please contact Wolfgang Runde at runde@lanl.gov.

Aluminum-26 (Al-26)is now available
To request a quotation for Al-26, please visit our website.

Yttrium-86 (Y-86)is now available on demand
To request a quotation for Y-86, please visit our website.

Actinium-225 (Ac-225)is available from proton bombardment of Th-232 targets at our accelerator sites at Brookhaven and Los Alamos National Laboratories and as a Th-229 decay product from Oak Ridge National Laboratory. To request a quotation for Ac-225, please visit our website. For further inquiries about the availability of Ac-225, please contact Wolfgang Runde.

Copper-67 (Cu-67)is currently available six months of the year from proton accelerator production at Brookhaven National Laboratory and will be available throughout the year from electron linac production at Argonne National Laboratory beginning in May. To request a quotation for Cu-67, please visit our website. For further inquiries about the availability of Cu-67, please contact Wolfgang Runde.

Cadmium-109 (Cd-109)can be produced upon request. Both accelerator and reactor-based production methods have been developed for Cd-109 at the DOE production sites. For further inquiries about the availability of Cd-109, please contact Wolfgang Runde.

Barium-133 (Ba-133)is scheduled to be available in 2018. The production of Ba-133 is scheduled and material will be available in 2018. For inquiries or availability of Ba-133, please contact Wolfgang Runde.

Strontium-89 (Sr-89)is available from two upcoming production campaigns. If sufficient demand is seen in response to these production runs, routine monthly production will be initiated. To request a quotation for Sr-89, please visit our website.

Announcing a Temporary Assignment Opportunity in the DOE Isotope Program - Headquarters (Germantown, MD)

Notice #64 - May 17, 2017

The Office of Nuclear Physics is seeking a scientist/engineer interested in assisting the DOE Isotope Program. We are seeking a candidate from a federal agency, university or national laboratory for a temporary period lasting six months to a few years on a detailee or Intergovernmental Personnel Act assignment. The benefit would not just be to our Office, but also to the individual. They will obtain a federal perspective of the DOE Isotope Program, which cannot be gained any other way and could be extremely beneficial to career development. We are interested in a variety of skill types and levels of experience.

The assignment involves providing scientific and technical expertise to the Isotope Program. This will entail supporting management in the identification of needed isotopes for the Nation, developing isotope production techniques, and assessing both ongoing projects and new R&D projects. Long-term career opportunities are expected within the Isotope Program in the future. This temporary assignment is also an excellent means for a scientist/engineer to gauge their interest in longer-term opportunities.

Individuals interested in this opportunity should contact Dr. Jehanne Gillo at Jehanne.Gillo@science.doe.gov.

Dr. Jehanne Gillo
Director, Facilities and Project Management Division
Office of Nuclear Physics, SC-26.2
Department of Energy

Director of DOE Isotope Program
email: Jehanne.Gillo@science.doe.gov.
phone: (301)-903-1455
SIPR: jehanne.gillo@hq.doe.sgov.gov.
IC: jehanne.gillo@doe.ic.gov.

Isotope Now Routinely Available, Test Batch Recipients Requested

Notice #63 - October 25, 2016

The U.S. Department of Energy's Isotope Program is pleased to announce the routine availability of the isotope copper-67 (Cu-67: t1/2= 2.58 days). A member of the group of isotopes known as theranostic (those with decay properties useful for both therapy and diagnostic imaging), Cu-67 (Eβ-end-point= 561.7 keV; Eγ = 184.6 keV) can be used as a single theranostic isotope or combined with the PET imaging isotope Cu-64 as a matched therapeutic/diagnostic pair. The matched pair provides several advantages. Most notably, the pair allows for using the same bifunctional chelating agent and radiochemistry during the labeling process. This simplifies calculating the biological clearance kinetics.

Brookhaven National Laboratory currently has the capability of producing Cu-67 in an on-demand schedule using proton bombardment of a Zn-68 target. Additional production capabilities will come online at the end of October, 2016, at Argonne National Laboratory. Argonne's Cu-67 production will employ a phototransmutation (γ,n) reaction, and will commence with weekly production for basic science and pre-clinical research. Operating a production schedule out of two National Laboratories, technical staff will be able to provide national distribution of highly pure Cu-67 on a regular basis and addresses a recommendation in the NSAC-I 2015 Long-Range Plan (http://science.energy.gov/~/media/np/nsac/pdf/docs/2015/2015_NSACI_Report_to_NSAC_Final.pdf).

Orders for Cu-67 may be placed using the NIDC's online catalog (https://www.isotopes.gov/catalog/). If you are interested in further information or in receiving test batch material from the phototransmutation route only, please contact Dr. Wolfgang Runde (runde@lanl.gov), Associate Director for Production Planning and Customer Relations, NIDC.

Quality Assurance Position Opening in the National Isotope Development Center (NIDC)

Notice #62 - September 26, 2016

The Oak Ridge National Laboratory (ORNL) seeks to hire a Quality Assurance Specialist. The position is in the Isotope Business Office (IBO) reporting to the IBO Manager. The QA management function is part of the National Isotope Development Center (NIDC). The NIDC QA Specialist is responsible for development, implementation, and maintenance of an integrated quality assurance system for the Department of Energy's Isotope Program (DOE-IP).

Click here to apply or visit http://www.ornl.gov/ornl/careers and reference NB50586073.

Major Duties/Responsibilities:

The QA Specialist works directly with the DOE-IP Site Program Managers to develop, implement, and maintain a quality system to meet regulatory, operational, and customer specifications for all stable and radioisotope products produced at the multiple sites. The approved QA system shall encompass the product life-cycle beginning with specifications in the NIDC catalog and ending with a certified product at the time of delivery to the customer. The QA Specialist shall be responsible for providing advice on compliance with the applicable quality assurance regulations at the IP sites and shall participate in audits conducted by regulatory authorities and customers.

Other responsibilities include:

Qualifications Required

This position requires the ability to obtain and maintain a DOE "Q" security clearance.

Qualifications Desired

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply.

Point of Contact:

Lauren Wurth
Recruiter
Oak Ridge National Lab
Wurthla@ornl.gov

The DOE Office of Science Graduate Student Research (SCGSR) program is now accepting applications

Notice #61 - August 31, 2016

Dear Colleague:

Beginning today, the Office of Science Graduate Student Research (SCGSR) program is accepting applications for the 2016 Solicitation 2. Applications are due 5:00 pm ET on Monday, November 21, 2016. Detailed information about the program, including eligibility requirements and access to the online application system, can be found at: http://science.energy.gov/wdts/scgsr/.

The SCGSR program supports supplemental awards to outstanding U.S. graduate students to conduct part of their graduate thesis research at a DOE national laboratory in collaboration with a DOE laboratory scientist for a period of 3 to 12 consecutive months – with the goal of preparing graduate students for scientific and technical careers critically important to the DOE Office of Science mission.

The SCGSR program is open to current Ph.D. students in qualified graduate programs at accredited U.S. academic institutions, who are conducting their graduate thesis research in targeted areas of importance to the DOE Office of Science. The research opportunity is expected to advance the graduate students' overall doctoral thesis/dissertation while providing access to the expertise, resources, and capabilities available at the DOE laboratories. The supplemental award provides for additional, incremental costs for living and travel expenses directly associated with conducting the SCGSR research project at the DOE host laboratory during the award period.

For any questions, please contact the SCGSR Program Manager, Dr. Ping Ge, at sc.scgsr@science.doe.gov.

U.S. Department of Energy, Office of Science

Isotope Program Stakeholders Meeting

Notice #60 - August 4, 2016

The Department of Energy's Isotope Program has set aside two days (Wednesday, October 5, and Thursday, October 6, 2016)for "one on one" meetings with stakeholders and interested commercial customers to discuss isotope supply and demand issues. The meetings will be held at the DOE Germantown, Maryland offices, or at a nearby location. The meetings provide an opportunity for the isotope community to discuss issues directly with the Director and Managers of the DOE Isotope Program. If you would like to make arrangements for a meeting, please contact Wolfgang Runde at runde@lanl.gov (cell: 505-231-0826) by September 2nd, 2016.

At-211 Partnership Agreement for University Isotope Production Finalized

Notice #59 - May 20, 2016

The U.S. Department of Energy's Isotope Program is pleased to announce the finalization of a partnership with the University of Washington's (UW) Department of Radiation Oncology located at the UW Medical Center in Seattle, Washington. Finalized on April 29th, the partnership allows UW to supply astatine-211 (At-211) for pre-clinical research through the National Isotope Development Center's (NIDC) Isotope Business Office (IBO). Operating on a weekly production schedule, the department's Medical Cyclotron Facility in conjunction with the Division of Radiochemistry processing laboratories and technical staff are able to provide regional distribution of highly pure At-211 to western states. Greater distances will result in increased decay during transit, but are possible. Addressing a recommendation in the NSAC-I 2015 Long-Range Plan (http://science.energy.gov/~/media/np/nsac/pdf/docs/2015/2015_NSACI_Report_to_NSAC_Final.pdf), the partnership with UW marks the first of many such agreements necessary to create a network of university-based isotope production centers capable of nationally providing short-lived radionuclides like At-211.

Orders for At-211 may be placed using the NIDC's online catalog (https://www.isotopes.gov/catalog/). If you are interested in further information, please contact Dr. Wolfgang Runde (runde@lanl.gov), Associate Director for Production Planning and Customer Relations, NIDC.

New Funding Opportunity Announcement Posted for Research, Development and Training in Isotope Production

Notice #58 - May 9, 2016

The U.S. Department of Energy's Isotope Program has posted a new funding opportunity announcement for Research, Development and Training in Isotope Production (DE-FOA-0001588). This funding opportunity announcement can be found online at the U.S. Department of Energy's Office of Science website, or at http://science.energy.gov/np/funding-opportunities. Eligibility for the FOA is limited to domestic institutions of higher education, domestic non-profit research institutions, and National Laboratories. The application deadline is 07/01/2016 at 5 PM Eastern Time.

More information may be found from this PDF file. If you have any questions please email Dr. Dennis Phillips at Dennis.Phillips@science.doe.gov.

Private Sector Survey Form

Notice #57 - May 2, 2016

PLEASE RESPOND DIRECTLY TO WOLFGANG RUNDE. HIS CONTACT INFORMATION HAS BEEN PROVIDED BELOW.

Special Notice: Survey Form – Private Sector

This announcement is intended to seek information from private companies on their potential isotope needs for the next five years and is not a Request for Proposal (RFP) or an Invitation for Bid (IFB), nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

The mission of the Isotope Development and Production for Research and Applications (IDPRA) Programwithin the Office of Nuclear Physicsof the Department of Energy's Office of Scienceis to develop, produce and distribute stable and radioactive isotope products that are in short supply and of critical importance to the Nation. The IDPRA Program manages the National Isotope Development Center (NIDC), which coordinates isotope production across Department of Energy (DOE) facilities and, for some isotopes, non-Federal facilities as well. This synopsis is to notify the public that the NIDC, on behalf of the IDPRA, seeks information from the community on anticipated needs of isotope products and potential supply shortages in the next five years. The IDPRA seeks this information to better understand the demand for isotopes used in research or commercial applications, including devices such as detectors and calibration sources and gauges that contain isotopes. Business and research entities should identify isotopes that are needed but are in short supply, in which they encounter uncertain supply issues, and/or that they expect an increase in demand that cannot be met by the current supply. The IDPRA, working with the NIDC, will use this information for strategic planning to enhance the reliability and availability of isotopes to the community. The information provided in this request form will assist the IDPRA to optimize production plans in the upcoming fiscal years and to plan strategically the future production of isotopes, gauging future demand, and evaluating and investing in the needs for isotope production technology development.

The NIDC is requesting that companies complete and submit the attached survey formto runde@lanl.govby June 3, 2016. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2016-2020. All information submitted is considered as highly business-sensitive and will not be shared or discussed outside the IDPRA. For workshop reports and additional information on the IDPRA program, please visit our website at http://science.energy.gov/np/research/idpra/.

Excluded from this request are helium-3 and molybdenum-99.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

Advances in Nuclear Nonproliferation Technology and Policy Conference: Bridging the Gaps in Nuclear Nonproliferation, September 25-28, 2016

Notice #56 - April 1, 2016

Dear Colleagues,

It is with great pleasure to invite you to the first American Nuclear Society (ANS) Advances in Nuclear Nonproliferation Technology and Policy Conference: Bridging the Gaps in Nuclear Nonproliferation. This conference will be held in Santa Fe, New Mexico, from September 25-28, 2016.The conference is co-sponsored by the ANS Nuclear Nonproliferation Policy Division, the ANS Isotopes and Radiation Division, and the ANS Trinity Section. A key objective of the meeting is to integrate the ever-dynamic issues in contemporary nuclear nonproliferation policy with innovations in state-of-the-art nuclear technology, capabilities and methods.

We believe that a presentation by you and your colleagues in the paper session "Production and Purification of Isotopes for Applications in Analysis, Metrology and Nuclear Forensics,"would be an excellent submission to share with our conference audience. All submissions are required to be in the form of an ANS Transaction, with guidelines and template available at www.ans.org/pubs/transactions. We ask that you please follow the submission instructions on the conference website (http://nnp.ans.org) for inclusion in the conference program and to register for the conference when registration opens. The deadline for paper submissions is April 1, 2016. To maximize the benefit of your attendance at the meeting, please plan to arrive at the meeting venue, the La Fonda on the Plaza Hotel in Santa Fe, NM, on or before September 25, 2016, and for international travelers, to depart from the USA after September 28, 2016. We recommend that international travelers book hotel reservations as early as possible once information is available through the conference website. The organizers request that speakers take responsibility for the payment of their travel and conference expenses.

Please click here to download the conference invitation letter as a PDF and click here to download the conference call for papers as a PDF.

Please feel free to forward this invitation to other interested colleagues. We look forward to seeing you in Santa Fe.

Michael E Fassbender, Session Organizer
Jill Cooley, Technical Co-Chair
Shaheen Dewji, Technical Co-Chair

Quality Assurance Position Opening in the National Isotope Development Center (NIDC)

Notice #55 - March 1, 2016

The Oak Ridge National Laboratory (ORNL) seeks to hire a Quality Assurance Specialist. The position is in the Isotope Business Office (IBO) reporting to the IBO Manager. The QA management function is part of the National Isotope Development Center (NIDC) and will report to the NIDC Associate Director for Logistics. The NIDC QA Specialist is responsible for development, implementation, and maintenance of an integrated quality assurance system for the Department of Energy's Isotope Program (DOE-IP).

Click here to apply or visit http://www.ornl.gov/ornl/careers and reference NB50549026.

Major Duties/Responsibilities:

The QA Specialist works directly with the DOE-IP Site Program Managers to develop, implement, and maintain a quality system to meet regulatory, operational, and customer specifications for all stable and radioisotope products produced at the multiple sites. The approved QA system shall encompass the product life-cycle beginning with specifications in the NIDC catalog and ending with a certified product at the time of delivery to the customer. The QA Specialist shall be responsible for providing advice on compliance with the applicable quality assurance regulations at the IP sites and shall participate in audits conducted by regulatory authorities and customers.

Other responsibilities include:

Qualifications Required

This position requires the ability to obtain and maintain a DOE "Q" security clearance.

Qualifications Desired

ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply.

Point of Contact:
Lorrin Howard
Recruiter
Oak Ridge National Lab
HOWARDLB@ORNL.GOV

The 16th International Workshop on Targetry and Target Chemistry Workshop (WTTC16) is Now Open for Abstract Submission

Notice #54 - February 18, 2016

Colleagues,

I'm writing to inform you that we have opened Abstract Submission for WTTC16 on the website, wttc16.us/abstracts.html. There you will find the required template and formatting information. We intend to accept submissions until April 30, 2016, and welcome accounts of your work. Registration for the meeting will open in 2 weeks with discounts for early arrangements and details to follow.

We look forward to hearing from you and to greeting you in Santa Fe later this year!

Jonathan Engle, for the WTTC16 Organizing Committee

Jonathan W Engle, PhD
Chairman, WTTC16
Scientist
Chemistry Division
Inorganic, Isotope and Actinide Group
Los Alamos National Laboratory
Telephone: (505) 695-6203
Email: jwengle@lanl.gov

The DOE Office of Science Graduate Student Research (SCGSR) Program is Now Accepting Applications

Notice #53 - February 17, 2016

Dear Colleagues,

The Department of Energy's (DOE) Office of Science is pleased to announce that the Office of Science Graduate Student Research (SCGSR) program is now accepting applications for the 2016 Solicitation 1. Applications are due 5:00 p.m. ET on Wednesday, May 11, 2016.

Starting from 2015 Solicitation 2, the SCGSR program is open to graduate students with Permanent Resident status, in addition to U.S. Citizens, who meet all other eligibility requirements. Detailed information about the program, including eligibility requirements and access to the online application system, can be found at: http://science.energy.gov/wdts/scgsr/and by downloading this informative PDF file.

The SCGSR program supports supplemental awards to outstanding U.S. graduate students to conduct part of their graduate thesis research at a DOE national laboratory in collaboration with a DOE laboratory scientist for a period of 3 to 12 consecutive months - with the goal of preparing graduate students for scientific and technical careers critically important to the DOE Office of Science mission.

The SCGSR program is open to current Ph.D. students in qualified graduate programs at accredited U.S. academic institutions, who are conducting their graduate thesis research in targeted areas of importance to the DOE Office of Science. The research opportunity is expected to advance the graduate students' overall doctoral thesis while providing access to the expertise, resources, and capabilities available at the DOE laboratories. The supplemental award provides for additional, incremental costs for living and travel expenses directly associated with conducting the SCGSR research project at the DOE host laboratory during the award period.

The Office of Science expects to make approximately 50 awards in 2016 Solicitation 1, for project periods beginning anytime between November 1, 2016 and February 28, 2017.

The 2014 program solicitation and the 2015 Solicitation 1 have resulted in awards to a total of 112 graduate students from more than 50 different universities to conduct thesis research at 15 DOE national laboratories.

The SCGSR program is sponsored and managed by the DOE Office of Science's Office of Workforce Development for Teachers and Scientists (WDTS), in collaboration with the six Office of Science research programs offices and the DOE national laboratories, and the Oak Ridge Institute of Science and Education (ORISE).

For any questions, please contact the SCGSR Program Manager, Dr. Ping Ge, at sc.scgsr@science.doe.gov.

U.S. Department of Energy, Office of Science

New Program Manager for Isotope Initiatives

Notice #52 - January 4, 2015

Dear All,

It is my great pleasure to introduce Dr. Joseph Glaser, who joined the Office of Nuclear Physics staff as a member of the DOE Isotope Program team on December 14, 2015. Dr. Glaser is the new Program Manager for Isotope Initiatives and his portfolio includes isotope program activities at Y-12 and Savannah River Plant, supply and demand of specific isotopes such as heavy water, He-3, Li-7 and Li-6, and other initiatives. Joe has over 15+ years of experience in international nuclear security and has a background in engineering. Most recently, he worked in the National Nuclear Security Administration as Senior Advisor to the Deputy Under Secretary for Counterterrorism. He is familiar with both the academic, national laboratory, and high level management environment.

I encourage all of you to start communicating with Joe on relevant efforts. He can be reached at Joseph.Glaser@science.doe.gov.

With best regards,

Jehanne

Dr. Jehanne Gillo, SES
Director, Facilities and Project Management Division
Director, DOE Isotope Program
Jehanne.Gillo@science.doe.gov

Isotope Program Sr-89 Samples Available for Evaluation

Notice #51 - December 11, 2015

The DOE Isotope Program is developing production of strontium-89 (Sr-89) and will engage in routine production if there is sufficient demand. The National Isotope Development Center is planning to have millicurie quantities of non-GMP strontium-89 (Sr-89) solution available for evaluation by potential users. The distribution of samples is planned for mid-January, 2016. Please reply to contact@isotopes.govto make arrangements if you are interested in receiving a sample.

Specifications for the sample material are predicted to be:

Isotope Program Stakeholders Meeting

Notice #50 - August 25, 2015

The Department of Energy's Isotope Program has set aside two days (Wednesday, October 28, and Thursday, October 29, 2015) for "one on one" meetings with interested commercial customers to discuss isotope supply and demand issues. The meetings will be held at the DOE Germantown, Maryland offices, or at a nearby location. The meetings provide an opportunity for the isotope community to discuss issues directly with the Director and Managers of the DOE Isotope Program.

If you would like to make arrangements for a meeting, please contact Wolfgang Runde at runde@lanl.gov(cell: 505-231-0826) by September 25, 2015.

Primary Point of Contact: Wolfgang Runde, NIDC Associate Director
runde@lanl.gov
Phone: (505) 231-0826

DOE/NSF Nuclear Science Advisory Committee (NSAC) Report

Notice #49 - August 3, 2015

Dear Colleague,

In 2014, the DOE/NSF Nuclear Science Advisory Committee (NSAC) was charged with conducting a new study of the opportunities and priorities for isotope research and production as part of an effort to develop a new long-range strategic plan for the DOE Isotope Program. In response, NSAC formed the NSAC Isotope (NSACI) sub-committee, chaired by Dr. Lawrence Cardman of the Thomas Jefferson National Accelerator Facility, to prepare a response. At the July 16, 2015 NSAC Meeting, the NSACI report was accepted. The report, "Meeting Isotope Needs and Capturing Opportunities For The Future", can be found at http://science.energy.gov/np/nsac/reports/.

If you would like to request a hardcopy of the report, please contact Brenda May at Brenda.may@science.doe.gov.

With best regards,
Jehanne Gillo

Dr. Jehanne Gillo, SES
Director, Facilities and Project Management Division
Director, DOE Isotope Program
Jehanne.Gillo@science.doe.gov

Call for Evaluation Studies for Dosimetry/Toxicity Analysis of Accelerator-Produced Actinium-225 (Ac-225)

Notice #48 - July 24, 2015

The NIDC is soliciting interest for independent evaluation studies of Ac-225 produced at our accelerator facilities at Brookhaven and Los Alamos National Laboratories. This evaluation, sponsored by the U.S. Department of Energy's Isotope Program in the Office of Nuclear Physics, is part of the ongoing analysis of product performance and acceptance criteria. The key feature and focus of the evaluation is the presence of co-produced, long-lived Ac-227 (t1/2= 21.8 y) observed in about 0.15-0.3 activity percent in the accelerator-derived product at the end of target bombardment. Ac-227/Ac-225 activity percent values as high as 0.5% could be anticipated in a research/clinical setting accounting for process and shipping times. We are seeking investigators who are interested in independently evaluating the dosimetry and toxicity impacts of the Ac-227 content relative to Ac-225 derived from Th-229 stock free from Ac-227. Proposed toxicity and dosimetry studies should focus on using the accelerator-produced product in an unchelated form (nitrate, citrate, etc.) or a simple labeled form (DOTA, DTPA for instance with no proprietary target vectoring agent) in order to represent a variety of clinical applications. Limited amounts of accelerator-produced Ac-225 (with Ac-227 contaminant) and Th-229 derived Ac-225 will be made available by the Isotope Program to support these focused studies. Please provide a brief outline of your evaluation plan, procedure, anticipated outcomes, material requirements, budgetary needs, and schedule to Wolfgang Runde, (runde@lanl.gov) by September 4, 2015. Evaluation studies should consider a budgetary constraint of $50-$100K and a 6-12 month period of performance to be executed in FY16.

Student Bursaries Available for Attending Radiochemistry-Related Symposia

Notice #47 - July 20, 2015

Financial Assistance:Funds have become available from the DOE Office of Science Isotope Program to help offset costs for students/trainees to attend selected radiochemistry-related symposia at Pacifichem 2015. Those symposia are: #363, Isotope production-Providing Important Materials for Research and Applications; #215, Chemistry of Molecular Imaging, and #11, Chemistry for Development of Theranostic Radiopharmaceuticals. The funds will be provided as bursaries of $1,000 per student award. The bursaries will be distributed to awardees after submission of copies of expense receipts from the meeting.

Eligibility: Financial assistance is available to those who are undergraduate students, graduate students, or Postdoctoral Fellows during the time of the Pacifichem 2015 meeting. Preference will be given to students/trainees from U.S. institutions.

Requirements: Applicants must provide: (1) a resume or curriculum vitae, (2) a letter from your supervisor indicating your status as a student or Postdoctoral Fellow at the time of the meeting, and that you will be able to attend the meeting if given the award, and (3) a brief statement of why you want to attend the symposia and how the bursary will help you attend.

Send Applications To:
Pacifichem 2015 Bursary Committee
c/o Prof. D. Scott Wilbur
Department of Radiation Oncology
Box 355016
University of Washington
Seattle, Washington 98105;

or email them dswilbur@uw.edu.

Applications should be received no later than September 1, 2015.

For additional information please contact: D. Scott Wilbur, dswilbur@uw.edu.

Click here to download the information sheet for this announcement.

Isotope Program Video Released

Notice #46 - June 25, 2015

A recently produced video describing the U.S. Department of Energy's Isotope Program and its importance to the nation is now available for viewing.

This video has been uploaded to the NIDC homepage; or you can go directly to YouTube to view it at https://www.youtube.com/watch?v=44mbZDKGb80. If you have any questions or comments, please contact Alexandr M. Sokolov at sokolovam@ornl.gov.

NIDC Has Launched New Online Quotation and Ordering Feature for Stable Isotope Research Customers

Notice #45 - May 26, 2015

The DOE Isotope Program is pleased to announce the release of new website tools for NIDC Preferred Customers within the Online Catalog of Isotope Products at https://www.isotopes.gov/. To apply for NIDC Preferred Customer status, you must be a researcher or administrator from a U.S. research institution or university and complete the online application at https://isotopes.gov/catalog/apply.php. Once your application has been reviewed and accepted by NIDC staff, you will receive an email with detailed instructions concerning your access to these new website tools.

The new website capabilities will allow NIDC Preferred Customers to securely generate quotations for selected stable isotope products in inventory and process them into online orders for an approved research application and delivery within the U.S. These tools will also allow for tracking of online order status, exporting of orders into an Excel format, browsing the history of orders for their associated institution, and updating of the NIDC Preferred Customer profile.

NIDC Launching New Online Quotation and Ordering Feature for Stable Isotope Research Customers

Notice #44 - May 8, 2015

The DOE Isotope Program is pleased to announce the upcoming release of new website tools for NIDC Preferred Customers within the Online Catalog of Isotope Products at https://www.isotopes.gov/. To apply for NIDC Preferred Customer status, you must be a researcher or administrator from a U.S. research institution or university. The new website capabilities will allow NIDC Preferred Customers to securely generate quotations for selected stable isotope products in inventory and process them into online orders for an approved research application and delivery within the U.S. These tools will also allow for tracking of online order status, exporting of orders into an Excel format, browsing the history of orders for their associated institution, and updating of the NIDC Preferred Customer profile. The URL for the online application will be announced with the live release of the new website capabilities later this month.

New Email Addresses for the NIDC

Notice #43 - May 5, 2015

This announcement is to inform our customers that the NIDC's contact and mailing list addresses have changed. Our new contact email address has been changed to "contact@isotopes.gov". Our mailing list address has been changed to "isotope-news@isotopes.gov". Please check your email client settings to ensure that these new email addresses are not being blocked by your spam filter. The old email addresses, "contact@isotopes.gov" and "isotope-news@ornl.gov" will be discontinued in the near future. If you encounter any issues, please contact the Isotope Business Office.

DOE Isotope Program Will NotAuction Helium-3 in 2015

Notice #42 - May 4, 2015

The DOE Isotope Program (DOE-IP) has decided not to auction helium-3 in 2015. The current market supply appears to be sufficient enough to meet the demand this year. If your organization needs helium-3 gas and you are unable to find a commercial supplier, please contact the NIDC.

DOE Isotope Program Announces Tungsten-188 (W-188) Is Now Available

Notice #41 - April 16, 2015

The National Isotope Development Center (NIDC) is pleased to announce resumption of the routine availability of W-188 in the form of liquid solution, or as a W-188/Re-188 generator. If you are interested in purchasing W-188, please request a price quotation using the Online Catalog of Isotope Products. For more information, please contact our office at contact@isotopes.gov.

https://isotopes.gov/news/notice41_image1.jpg
The W-188/Re-188 Generator System is pictured above.

DOE Isotope Program Announces Restart of Bulk High Specific Activity (HSA) Co-60 Production

Notice #40 - April 13, 2015

Dear Colleagues,

The DOE Isotope Program (DOE IP) announces the resumption of target irradiations at the Idaho National Laboratory's (INL) Advanced Test Reactor (ATR) to provide bulk HSA cobalt-60 (Co-60) for sealed-source production. Irradiations had ceased in 2012 after the failure of a Co-60 production target. The DOE IP organized and supported a team of engineers from INL and Oak Ridge National Laboratory (ORNL) to design a new production target, and they also consulted with representatives from the commercial sector, International Isotopes Idaho Inc. (INIS), and GE Power and Water (GE) for target design optimization. Details were presented at the 2014 International Group on Research Reactors Conference. For more information and to request a quote, please contact contact@isotopes.gov.

The 3-D image of the new robust end-cap closure for the re-designed target is shown below on the left. The image below on the right shows the new target's multi-channel loading feature which allows for increased production capacity.

DOE Isotope Program Announces Opening – Program Manager for Isotopes Facilities

Update:Notice #39 - May 4, 2014

Dear Colleagues,

This is an update to the original March 31, 2015, NIDC announcement regarding the Isotopes Facilities Program Manager position. The position will be posted on www.usajobs.govon June 15and will close on July 15. Please distributeto interested parties. This is an important position within the DOE Isotope Program. Serious inquiries may be directed to me.

Best regards,

Dr. Jehanne Gillo, SES
Director, Facilities and Project Management Division
Director, DOE Isotope Program
Jehanne.Gillo@science.doe.gov

Office of Science for Nuclear Physics
Department of Energy

DOE IP Job Opening - Program Manager for Isotopes Facilities

Notice #39 March 31, 2015

Dear Colleagues,

The Office of Nuclear Physics is preparing to advertise for a permanent federal position at the Department of Energy (DOE) Headquarters in Germantown, Maryland. This person would be reporting directly to me and would be a member of the federal team managing the DOE Isotope Program. The current Program Manager for Isotope Facilities, Dr. Marc Garland, will remain in the program, but has taken on other duties within the Isotope Program. This new Program Manager will focus on the operations of Isotope Facilities within the scope of the isotope program, including their needed resources and productivity. This Program Manager will also be responsible for the performance of these facilities, strategic planning associated with the facilities, and the development of new production capabilities within the program. It is expected that this position will be advertised in the next 4-6 weeks on https://www.usajobs.gov, and the opening period will not be very long. Therefore, we wanted to give advance warning to the community. Please do distribute this email to any interested parties. Serious inquiries may contact me for further information.

Best regards,

Dr. Jehanne Gillo, SES
Director, Facilities and Project Management Division
Director, DOE Isotope Program
Jehanne.Gillo@science.doe.gov

Office of Science for Nuclear Physics
Department of Energy

DOE Isotope Program Announces Availability of Radium-224/Lead-212 Generators

Notice #38 - March 13, 2015

The DOE Isotope Program (DOE IP) is pleased to announce the availability of radium-224/lead-212 generators. Lead-212 (10.6 hour half-life) and its daughter bismuth-212 (60.6 minute half-life) are of interest in targeted alpha-particle therapy of cancer, including breast and ovarian cancers and melanoma. Research in progress is demonstrating the effectiveness of these isotopes in destroying cancer cells while limiting damage to healthy cells due to specific biological targeting of the isotopes to the cancer cells and the short range of alpha particles in tissue.

In response to the discontinuation of availability of these generators from a private initiative that had attempted to commercialize generator production, the DOE IP initiated the establishment of a production capability at the Oak Ridge National Laboratory (ORNL) through the recovery of thorium-228 from uranium-232. The thorium-228 (1.9 year half-life) serves as a cow for the provision of its decay product radium-224 (3.7 day half-life) which is loaded on a generator from which either lead-212 or bismuth-212 can be eluted. The radium-224 generator, using the same design as the ORNL actinium-225/bismuth-213 generator, has been tested by two researchers with extensive experience in lead-212/bismuth-212 targeted therapy and has been found to perform exceptionally well. The generator (see figures below) is now routinely available for ordering through the National Isotope Development Center catalog. Generators are shipped with instructions for eluting lead-212 and bismuth-212.

Radium-224/Lead-212 generator as shipped in lead shield (left) and with the shield cap removed to show the tubing connections to the column (right).

Increasing the availability of alpha-emitters for medical research was the highest priority recommendation of the Nuclear Science Advisory Committee's report "Compelling Research Opportunities using Isotopes," (http://science.energy.gov/~/media/np/pdf/NSACI_Final_Report_Charge1.pdf).

In addition to the routine provision of actinium-225, thorium-227, and radium-223, investing in research on accelerator production of actinium-225, and supporting development and production of astatine-211 at several universities, the production of radium-224/lead-212 generators now provides a pathway for researchers' utilization of all of the most-promising alpha-emitters for therapy of cancer and other diseases.

Bk-249 Availability

Notice #37 - January 20, 2015

The NIDC will have milligram quantities of berkelium-249 (Bk-249) available during late-March/early-April for interested researchers. If you are interested in purchasing, please request a price quotation at the Bk-249 Isotope Catalog Webpage. Please reply by January 30, 2015.

Isotope Program Customer Meetings

Notice #36 - November 20, 2014

The Department of Energy's Isotope Program has set aside two days (Thursday, January 8, and Friday, January 9)for "one on one" meetings with interested commercial isotope customers to discuss isotope supply and demand issues. The meetings will be held at the DOE Germantown, Maryland office, or at a nearby location. The meetings provide an opportunity for the isotope community to discuss isotope issues directly with the Director and Managers of the DOE Isotope Program.

If you are interested and would like to make arrangements for a meeting, please contact Wolfgang Runde at runde@lanl.gov(cell: 505-231-0826) by December 5, 2014.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

Special Notice: Private Sector Survey Form

Notice #35 - October 10, 2014

PLEASE RESPOND DIRECTLY TO WOLFGANG RUNDE. HIS CONTACT INFORMATION HAS BEEN PROVIDED BELOW.

This announcement is intended to seek information from private companies on their potential isotope needs for the next five years and is not a Request for Proposal (RFP) or an Invitation for Bid (IFB), nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

The mission of the Isotope Development and Production for Research and Applications (IDPRA) Programwithin the Office of Nuclear Physicsof the Department of Energy's Office of Scienceis to develop, produce and distribute stable and radioactive isotope products that are in short supply and of critical importance to the Nation. The IDPRA Program manages the National Isotope Development Center (NIDC), which coordinates isotope production across Department of Energy (DOE) facilities and, for some isotopes, non-Federal facilities as well. This synopsis is to notify the public that the NIDC, on behalf of the IDPRA, seeks information from the community on anticipated needs of isotope products and potential supply shortages in the next five years. The IDPRA seeks this information to better understand the demand for isotopes used in research or commercial applications, including devices such as detectors and calibration sources and gauges that contain isotopes. Business and research entities should identify isotopes that are needed but are in short supply, in which they encounter uncertain supply issues, and/or that they expect an increase in demand that cannot be met by the current supply. The IDPRA, working with the NIDC, will use this information for strategic planning to enhance the reliability and availability of isotopes to the community. The information provided in this request form will assist the IDPRA to optimize production plans in the upcoming fiscal years and to plan strategically the future production of isotopes, gauging future demand, and evaluating and investing in the needs for isotope production technology development.

The NIDC is requesting that companies complete and submit the attached survey formto runde@lanl.govby October 29, 2014. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2015-2019. All information submitted is considered as highly business-sensitive and will not be shared or discussed outside the IDPRA. For workshop reports and additional information on the IDPRA program, please visit our website at http://science.energy.gov/np/research/idpra/.

Excluded from this request are helium-3 and molybdenum-99.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

Partial Germanium-68 (Ge-68) Production Withdrawal

Notice #33 - September 5, 2014

Among the many radioisotopes, the Department of Energy's Isotope Program has been producing and distributing germanium-68 (68Ge) for research and commercial applications for many years. Germanium-68 has a half-life of 271 days and decays to the radionuclide gallium-68 (68Ga, half-life 68 minutes). Germanium-68 has been mainly utilized as a reference source for the calibration and normalization of 2D and 3D Positron Emission Tomography (PET) imaging systems. In recent years, the 68Ge/68Ga generator system has attracted increasing interest as an excellent device to provide the short-lived radioisotope 68Ga. The positron-emitting 68Ga can be easily eluted from the 68Ge/68Ga generator system, and utilized for the radiolabeling of peptides and other molecules used in diagnostic applications in nuclear oncology, such as neuroendocrine tumor imaging. Recently, the pharmaceutical 68Ge/68Ga generator has received European approval for the clinical development of highly specific diagnostic agents, thus potentially facilitating the development and applications of 68Ga technologies.

With its reliable production and supply of 68Ge over the past years, the DOE Isotope Program has met the continuously increasing market demand and has enabled the research community to develop new, promising devices for cancer diagnostics. The prospects of the increasing utilization of 68Ga in diagnostic PET procedures have made the commercial production of 68Ge a viable enterprise and the DOE Isotope Program has now successfully transferred some Ge-68 production responsibility to the private sector.

The DOE Isotope Program recently conducted a rigorous process to evaluate domestic production capacities and their ability to reliably and economically meet domestic market demand. At the end of the assessment, and in consideration of community input, the DOE Isotope Program concluded that the demand for 68Ge for the fabrication of PET calibration sources was adequately satisfied with the addition of a new domestic producer. However, without the production of 68Ge by the DOE Isotope Program for use in 68Ge/68Ga generators, a sole domestic commercial producer would not represent effective competition in the supply of 68Ge in support of the Nation's best interests in the research and development of 68Ga radiopharmaceuticals. As a result, the DOE Isotope Program announced in the Federal Register (79 FR 51985, September 2, 2014), that it will withdraw from the distribution of 68Ge for the manufacturing of PET calibration sources, but continue in the production and distribution of 68Ge for use in the manufacture of 68Ge/68Ga generators. In all cases, the DOE Isotope Program will make customers aware of the new domestic production capabilities and encourage customers to consider alternate suppliers to the DOE. The DOE Isotope Program's 68Ge customers will be required to sign an end-use statement to assure that the 68Ge will be used only in the fabrication of 68Ge/68Ga generators. Further details are provided in the Federal Register notice http://www.gpo.gov/fdsys/pkg/FR-2014-09-02/pdf/2014-20749.pdf.

The DOE Isotope Program develops isotope production and nurtures applications of isotopes until such time as private industry develops the technology and is able to meet the needs of the community. The DOE Isotope Program does not compete with private industry for isotope production when commercial isotope production can meet domestic demand in a reliable and cost-effective manner, and in the context of effective competition. The partial transfer of the production and distribution of 68Ge to the private sector is considered a story of success by the DOE Isotope Program, and indicative of a successful nurturing of this isotope within the medical community, until its production became economically viable for industry. The transfer of 68Ge production to the private sector becomes the latest success that began with the Manhattan Project's 1946 shipment of carbon-14 to researchers, and includes the development of the molybdenum-99/technetium-99m generator system, the most widely used medical diagnostic isotope in the world.

Helium-3 Auction in Summer 2014

Notice #32 - August 1, 2014

For the third year, DOE is planning to conduct a Helium-3 (He-3) auction. 4,000 liters of He-3 gas will be available for bids in a process similar to the one conducted late in 2013. DOE's Solicitation for Bidsfor the purchase of He-3 gas has been posted for viewing and downloading at this website's He-3 auction pageon August 1, 2014.

After the Solicitation for Bidsis issued, DOE will accept questions submitted to the following email address: He3auction@science.doe.gov, no later than 5:00 P.M., on August 22, 2014.

DOE will post all questions received and their corresponding answers on the NIDC website no later than 5:00 P.M., on August 29, 2014.

On September 19, 2014, all valid bids to purchase He-3 gas must be received by the U.S. Department of Energy no later than 5:00 PM. All valid bids to purchase He-3 gas shall consist of a submittal letter and the attached order form, submitted electronically by email to He3auction@science.doe.gov. A confirmation of receipt will be sent electronically within the next working business day. Bids will not be accepted via U.S. Postal Service mail.

Microgram Quantities of Berkelium-249 Available

Notice #31 July 23, 2014

The NIDC has microgram quantities of berkelium-249 available for interested researchers. You may request a price quotation at http://isotopes.gov/catalog/product.php?element=Berkelium&type=rad&rad_product_index=7.

Applications Being Accepted for the SCGSR Program and Submit Your Abstracts for Pacifichem 2015

Notice #30 - July 15, 2014

  1. The Office of Science has announced the opening for applications to the 2014 DOE Office of Science Graduate Student Research (SCGSR) Program. Isotope Production Research is a topic of interest for this announcement. Applications are due no later than September 24, 2014, at 5:00 p.m., EST. Interested persons may get further information about the program at http://science.energy.gov/wdts/scgsr/how-to-apply/.
  2. The International Chemical Congress of Pacific Basin Societies will hold Pacifichem 2015 in Honolulu, Hawaii, December 15-20, 2015. A symposium entitled, "Isotope Production--Providing Important Materials for Research and Applications, (Symposium #363)" is being organized for this meeting in the Inorganic Topic Area. A direct link to the description of this symposium is at http://www.pacifichem.org/symposiadesc2015/c_symp_363.htm. Abstracts for this symposium will be accepted from January 1 through March 1, 2015. General information about Pacifichem 2015 may be found at http://www.pacifichem.org/general-information/.

Funding Opportunity Announcement DE-FOA-0001136 Leveraging Isotope Program Resources and Enhancing Facilities for Isotope Production and Research

Notice #29 - April 13, 2014

The Department of Energy's Isotope Development and Production for Research and Applications program has issued a Funding Opportunity Announcement that seeks applications for isotope production initiatives that enhance the availability of isotopes that are in short supply. The summary from the FOA is displayed below; the full solicitation (DE-FOA-0001136) can be found on http://www.grants.gov.

If you have any questions, please contact Marc Garland, marc.garland@science.doe.gov, 301-903-9576.

SUMMARY

The U.S. Department of Energy's Office of Science, Office of Nuclear Physics hereby announces its interest in receiving applications for initiatives that will enhance the availability of isotopes that are in short supply and critical to the Nation. This announcement is divided into two very different tracks; please read the announcement carefully to determine which track you wish to apply. This announcement is administered by the Isotope Development and Production for Research and Applications (IDPRA, the "DOE Isotope Program") managed by the Office of Nuclear Physics within the Office of Science.

Track I of this FOA seeks applications that seek to make use of DOE's technical expertise and knowledge in the production of isotopes, in a manner that furthers the mission of the DOE Isotope Program to enhance the availability of isotopes in short supply. Applications submitted to Track I will not receive financial assistance awards in the form of grants or cooperative agreements. Rather, the DOE Isotope Program will facilitate the creation of relationships to make use of DOE's technical expertise. These relationships may take the form of Work-For-Others agreements at a DOE National Laboratory, a Cooperative Research and Development Agreement (CRADA), or other non-procurement formats.

Track II of this FOA seeks applications that request financial assistance to enhance the capability of existing facilities used for research and isotope production that are located at regionally-accredited institutions of higher education or not-for-profit organizations, and that further the mission of the DOE Isotope Program to enhance the availability of isotopes in short supply. Applications submitted to Track II must be for the enhancement of facilities such as a hospital – or university-based accelerator that is used for research and isotope production.

Within both tracks, applications focused only on R&D associated with isotope production will not be considered. Applications for this FOA should be geared towards isotope production opportunities. This FOA is intended to identify the opportunities that best utilize the DOE Isotope Program's limited resources and are in the best interests of the Nation and the DOE Isotope Program. Applications are not restricted to a particular technology.

Organizational Change

Notice #28 - April 8, 2014

This notice is to announce a strategic change in the organization of the Department of Energy's Isotope Development and Production for Research and Applications Program (DOE Isotope Program) as part of the Office of Nuclear Physics' continuing effort to optimize the effectiveness and impact of this very important DOE program. Since the Isotope Program moved to the Office of Nuclear Physics in 2009, the evolution of the program and the activities in which it is involved have broadened dramatically. Due to the level of coordination needed to support this highly complex program, the National Isotope Development Center (NIDC) functions most effectively and efficiently as a direct extension of the DOE Isotope Program. I have asked Dr. Marc Garland to lead the operation of the NIDC and to work directly with NIDC Associate Directors Dr. Wolfgang Runde and Mr. Mitch Ferren. This change, effective July 1, 2014, will ensure the highest level of communication and coordination between NIDC and the DOE Isotope Program, as both operations jointly face the significant complexity and challenge of today's highly dynamic isotope marketplace.

I would also ask you to join me in expressing sincere gratitude to Dr. Robert Atcher, who has worked tirelessly and diligently to lead the NIDC since its inception, establishing new, effective means of timely communication with the Isotope Program's multi-faceted stakeholder communities, and significantly advancing public outreach through innovative means, including a new newsletter and a dramatically improved NIDC website. In addition to these seminal contributions, Dr. Atcher has played a leading role in facilitating a new collective understanding of the priority of research isotopes of interest for that stakeholder community. He was highly effective in working to address emerging issues, such as the availability of oxygen-18 and carbon-14, and the recall of strontium-82/rubidium-82 generators. Dr. Atcher plans to continue his landmark contributions by exploring possible future isotope production and R&D opportunities at Los Alamos National Laboratory. He will also reinvigorate his research interests in the application of alpha emitters for the treatment of disease. Please join me in thanking Dr. Atcher for his numerous contributions to date, and for accepting this new challenge potentially of great importance for the future of the DOE Isotope Program.

Dr. Jehanne Gillo

Director, DOE Nuclear Physics Facilities and Projects Division
Director, DOE Isotope Development and Production for Research and Applications Program

Clarification of the National Isotope Development Center (NIDC)

Notice #27, "International Shortage of Helium-3 Mitigated", dated March 12, 2014
Update: Notice #27 - April 1, 2014

The Isotope Program would like to thank those who have commented on and/or inquired about the helium-3 (He-3) shortage mitigation discussed in NIDC Notice #27, published on March 12, 2014. The intent of the notice was to publicize the highly effective actions of the United States Government to mitigate the He-3 shortage through a number of actions. Notice #27 did not in any way intend to imply that the policies and practices of any Federal agency, which has implemented the guidance issued by the National Security Council (NSC) Interagency Policy Committee (IPC) as it relates to He-3 future allocations, have changed.

In reality, it is only through continued diligent mitigation efforts being pursued across the federal complex that the limited federal production and current inventory of He-3 will continue to meet high priority federal needs for decades to come. These mitigation efforts include use of alternative technologies, the reuse and recycle of He-3 from obsolete and excessed equipment, annual review and action by the Federal Interagency Group (IAG) to assess and prioritize He-3 allocations, and continued adherence to the IPC guidance.

International Shortage of Helium-3 Mitigated

Notice #27 - March 12, 2014

Helium-3 (He-3) is a stable isotope supplied mainly by artificial operations. The sole source of domestic He-3 is from the decay of radioactive tritium produced for the Department of Energy's (DOE) nuclear weapons stockpile. The He-3 gas is separated from tritium located at the National Nuclear Security Administration's (NNSA) Savannah River Site (SRS). As the designated office for isotope production and distribution, the Office of Nuclear Physics Isotope Program in DOE's Office of Science administers He-3 extraction and distribution.

As the Department's excess He-3 became available in the past 60 years, it has been widely used in government and commercial applications including medical diagnostics, cryogenics, basic and applied materials research, and neutron detection and measurement applications including research, oil and gas exploration, and highway construction. Demand increased dramatically in the past decade owing to expanded use of He-3 gas in neutron detectors for national security, nonproliferation, defense, border security, and homeland security.

In March 2009, an interagency He-3 Integrated Product Team (IPT) composed of DOE, NNSA, Department of Homeland Security (DHS), Department of Defense, and other government agencies was formed to address decreasing supply of and increasing demand for He-3. The IPT (now called the InterAgency Group (IAG) with representation from fourteen different federal agencies) reports to a higher level interagency group, called the Sub-IPC (Interagency Policy Committee), chaired by the National Security Council. The Director of the DOE Isotope Program chairs the activities of the He-3 IAG. Annually, the IAG collects He-3 demand information from the Federal complex, identifying and scrutinizing the requests for gas needed to accomplish Federal missions.

As a result of the deliberations of the IAG and close interagency coordination, impacts of the 2008 shortage have been alleviated. Over the past several years, the IAG considered strategies to increase supply including: (1) seeking He-3 supply from foreign countries, (2) encouraging He-3 recycling and reuse, (3) investigating techniques to increase He-3 extraction efficiency, and (4) seeking new He-3 production methods. Through the efforts of the IAG, domestic demand has decreased dramatically by a combination of actions including prioritization, alternative technologies research and deployment, more efficient applications, reuse and recycling; federal demand has decreased from an annual demand of 70,000 liters to less than 10,000 liters. With the mitigation efforts fostered by the He-3 IAG, the current He-3 supply is estimated to meet the federal domestic demand for several decades. The DOE currently sees its role in new supply as a facilitating role, and is having discussions with industry to see how it can help industry in increasing domestic He-3 supply.

Silicon-32 is Now Available

Notice #26 - September 27, 2013

Silicon-32 (Si-32) has been added to the NIDC inventory and is now available for sale. The Si-32 is offered in 0.1 M NaOH solution with an activity concentration of ~11.8 microcuries/milliliter and a specific activity of ~0.56 microcuries/microgram. Please visit the NIDC website at www.isotopes.govand request a quotation.

Special Notice: Survey Form – Private Sector

Notice #25 - September 9, 2013

PLEASE RESPOND DIRECTLY TO WOLFGANG RUNDE. HIS CONTACT INFORMATION HAS BEEN PROVIDED BELOW.

This announcement is intended to seek information from private companies on their potential isotope needs for the next five years and is not a Request for Proposal (RFP) or an Invitation for Bid (IFB), nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

The mission of the Isotope Development and Production for Research and Applications (IDPRA) Programwithin the Office of Nuclear Physicsof the Department of Energy's Office of Scienceis to develop, produce and distribute stable and radioactive isotope products that are in short supply and of critical importance to the Nation. The IDPRA Program manages the National Isotope Development Center (NIDC), which coordinates isotope production across Department of Energy (DOE) facilities and, for some isotopes, non-Federal facilities as well. This synopsis is to notify the public that the NIDC, on behalf of the IDPRA, seeks information from the community on anticipated needs of isotope products and potential supply shortages in the next five years. The IDPRA seeks this information to better understand the demand for isotopes used in research or commercial applications, including devices such as detectors and calibration sources and gauges that contain isotopes. Business and research entities should identify isotopes that are needed but are in short supply, in which they encounter uncertain supply issues, and/or that they expect an increase in demand that cannot be met by the current supply. The IDPRA, working with the NIDC, will use this information for strategic planning to enhance the reliability and availability of isotopes to the community. The information provided in this request form will assist the IDPRA to optimize production plans in the upcoming fiscal years and to plan strategically the future production of isotopes, gauging future demand, and evaluating and investing in the needs for isotope production technology development.

The NIDC is requesting that companies complete and submit the attached survey formto runde@lanl.govby September 30, 2013. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2014-2018. All information submitted is considered as highly business-sensitive and will not be shared or discussed outside the IDPRA. For workshop reports and additional information on the IDPRA program, please visit our website at http://science.energy.gov/np/research/idpra/.

Excluded from this request are helium-3 and molybdenum-99.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

Third Workshop on Isotope Harvesting at FRIB

Notice #24 - September 6, 2013

Third Workshop on Isotope Harvesting at FRIB
October 14-16, 2013
Washington University Medical School
St. Louis, Missouri

Please feel free to share with others that may be interested.

Updates:

The Facility for Rare Isotope Beams (FRIB) will be a new national user facility for nuclear science, funded by the DOE and operated by Michigan State University. The facility, scheduled for completion in 2018 will produce intense beams of rare isotopes that will provide a broad range of new information about the properties of these isotopes and, for example will allow better understanding of the origin of the elements and the evolution of the cosmos. While the standard mode of FRIB operation will produce a single rare isotope beam for a primary user, the fragmentation or fission of the production beam will produce many other long-lived isotopes that could be harvested and used for other applications. In many cases, these isotopes could be collected while a FRIB primary user performs an experiment, with no impact on the primary user.

The first workshop on Isotope Harvesting at FRIB, held in Santa Fe in 2010, focused on identifying long-lived radioisotopes that FRIB could produce for various applications, such as medical diagnostics and therapy, homeland security, stockpile stewardship, astrophysics, fundamental interactions, nanoprobes for materials science, and industrial and environmental tracers. The second workshop on Isotope Harvesting at FRIB was held in summer 2012 on the campus of Michigan State University and concentrated on experimental design considerations of isotope harvesting at FRIB. The third, two-day workshop, will continue to focus more specifically on what isotopes are likely within reach with the existing design of the FRIB production target facility and what is needed to harvest the isotopes at FRIB. An example of medical isotope production and radiochemistry facilities will be available to tour at Washington University School of Medicine. Participants will help to prioritize the list of radioisotope applications and consider possible experiments that could be carried out with the FRIB facility. Meals and local accommodation will be provided for preregistered participants, and the workshop will be held on the School of Medicine campus within walking distance of the workshop hotel. A block of rooms has been set aside at the Parkway hotel:
http://www.theparkwayhotel.com/.

There is light rail service from the St. Louis airport directly to the Medical School campus and hotel. Details on the meeting arrangements and the proposed workshop agenda is available on-line: http://meetings.nscl.msu.edu/IsotopeWorkshop2013/

The conference organizers will be in contact with you to confirm travel arrangements. If you have any questions please contact Graham Peaslee at: peaslee@hope.edu.

Funded by DOE Office of Science and hosted by Michigan State University
Organizers: Suzanne Lapi, Graham Peaslee, and David Morrissey
Location: Washington University, St. Louis, Missouri

A printable version of this announcement can be found at: http://meetings.nscl.msu.edu/IsotopeWorkshop2013/

Isotope Program Customer Meetings

Notice #23 - August 20, 2013

The Department of Energy's Isotope Program has set aside two days (Wednesday, October 30, and Thursday, October 31st)for "one on one" meetings with interested commercial isotope customers to discuss isotope supply and demand issues. The meetings will be held at the DOE Germantown, Maryland office, or at a nearby location. The meetings provide an opportunity for the isotope community to discuss isotope issues directly with the Director and Managers of the DOE Isotope Program.

If you are interested and would like to make arrangements for a meeting, please contact Wolfgang Runde at runde@lanl.gov (cell: 505-231-0826) by September 15, 2013.

Phase I SBIR and STTR proposals for FY 2014 Released

Notice #22 - August 5, 2013

DOE has released the call for Phase I SBIR and STTR proposals for FY 2014. There are specific instructions relative to the areas of interest to the DOE Isotope Program. Please refer to the website (http://science.energy.gov/sbir/) for more information on the program.

DOE SBIR/STTR FY 2014 Phase I (Release 1) Topics Available

The Department of Energy (DOE) has posted the topics for Release 1 of the DOE FY2014 SBIR/STTR Phase I Funding Opportunity Announcement (FOA) on their SBIR/STTR website. There are 40 topics available from among the following 7 participating DOE Research Programs (also referred to as Program Areas):

The 180-page Topic document contains descriptions of all of the topics and associated subtopics; links to Program Area additional information; subtopic references and contact emails; and a schedule of important dates regarding the FOA.

The Topic document also refers to the fact that selected topic and subtopics contained in the FOA are designated as a Technology Transfer Opportunity (TTO) which is an opportunity to leverage technology that has been developed at a DOE National Laboratory. Each TTO will be described in a particular subtopic and additional information may be obtained by using the link in the subtopic to the DOE National Laboratory that has developed the technology. Typically the technology was developed with DOE funding of either basic or applied research at a DOE National Laboratory and is available for transfer to the private sector. Page 1 and 2 of the FOA contains a series of questions and answers regarding TTOs.

FedBizOpps Announcement Released for He-3 Auction in Summer 2013

Notice #21 - July 30, 2013

The DOE Isotope Program is pleased to announce an upcoming auction for 4,000 liters of He-3 gas. Please see this FedBizOpps.gov (Federal Business Opportunities) web linkfor more details.

Please direct any questions regarding this notice to:

Joel Grimm
Program Manager
Facilities and Project Management Division
Office of Nuclear Physics
U.S. Department of Energy
SC-26.2, Germantown Building
1000 Independence Avenue
Washington, D.C. 20585-1290
Email: Joel.Grimm@science.doe.gov

He-3 Auction in Summer 2013

Notice #20 - July 26, 2013

For the second year, DOE is planning to conduct a Helium-3 (He-3) auction. 4,000 liters of He-3 gas will be available for bids in a process similar to the one conducted late in 2012. DOE's Invitation for Bids (IFB)for the purchase of He-3 gas is scheduled to be posted for viewing and downloading on the NIDC website by August 9, 2013.

After the Invitation for Bids is issued, DOE will accept questions submitted to the following email address: He3auction@science.doe.gov, no later than 5:00 P.M., on August 23, 2013. The Bid process is currently slated to come to a close on September 17, 2013.

Copper-67 Shipments are Scheduled for July 23, 2013

Notice #19 - July 12, 2013

A Copper-67 (Cu-67) production run is scheduled for this month, with shipments scheduled to occur on July 23, 2013. The Cu-67 is priced at $295.00 per millicurie, plus $300.00 for packaging. Please contact Mitch Ferren (email address ferrendm@ornl.gov) of the Isotope Business Office by COB Monday, July 15, 2013, if you are interested in purchasing material.

User Meeting at June SNMMI Meeting in Vancouver

Notice #18 - May 30, 2013

The National Isotope Development Center will be hosting a User Meeting during the Society of Nuclear Medicine and Molecular Imaging annual meeting in Vancouver. The meeting is an informal opportunity to discuss DOE isotope issues with program representatives. All are welcome.

The User meeting will be held on Sunday, June 9th at 6:30 PM., at the following location:
Vancouver Marriott Pinnacle Downtown
Ambleside I Room on the 4th floor
1128 West Hastings Street
Vancouver, BC V6E 4R5

For further information, please stop by the U.S. DOE Isotope Program Booth #1334.

Isotope Production Symposium

Notice #17 - March 22, 2013

Isotope Production Symposium at Upcoming ACS Meeting in New Orleans

A symposium has been organized at the upcoming American Chemical Society meeting to honor the memory of Prof. Michael Welch who died in 2012. The symposium focuses on a wide range of isotope production techniques for both enriching stable isotopes and producing radioisotopes from accelerators and reactors. The symposium will be held from 8:30 AM to 5:30 PM on Sunday, April 7 and Monday April 8, 2013. The symposium will be held in the Fulton Room of the Hampton Inn and Suites Convention Center, 1201 Convention Center Blvd, New Orleans. The hotel is right across the street from the Convention Center. The symposium is part of the program for the Division of Nuclear Chemistry and Technology of the ACS. The matrix for the Division's program can be found by clicking here.

Please direct any questions regarding the Isotope Production Symposium to:

Dennis R. Phillips
Program Chair and Symposium Organizer
Phone: (301) 903-7866
Email: dennis.phillips@science.doe.gov

Copper-67 Production

Notice #16 - February 7, 2013

Dear Isotope User:

The National Isotope Development Center (NIDC) is pleased to announce the initiation of scheduled production campaigns of the radioisotope copper-67 (Cu-67). The next production campaign is scheduled for March 2013. To review product specifications and request a price quotation, please visit the NIDC on-line catalog at isotopes.gov/catalog/.

Please direct any questions regarding Cu-67 to:

Isotope Business Office
Phone: (865) 574-6984
Fax: (865) 574-6986
Email: contact@isotopes.gov
Catalog: http://isotopes.gov/catalog/

He-3 Sales

Notice #15 - October 18, 2012

Dear Colleagues,

He-3 Sales Solicitation Amendment

DOE has amended its Sales Solicitation provisions to accept a minimum bid amount of 25 liters for the purposes of this auction only. Bidders may bid for one or multiple lots. If a Bidder requests a total amount of He-3 up to and including 100 liters, the lot sizes must be in increments of 25 liters or a single 100 liter lot. If a Bidder requests 100 liters of He-3 or more, the lot sizes must be in increments of 100 liters. The end date of the auction is revised to accommodate this change. All other parameters remain the same. All valid bids to purchase He-3 gas must follow the instructions in the amended Sales Solicitation, provided at http://www.isotopes.gov/he-3auction2012/index.html, using the order form provided online, and submitted electronically by email to He3auction@science.doe.gov by November 14, 2012. Please note that future auctions may revert back to a 100 liter minimum lot size.

Please submit all questions to He3auction@science.doe.gov

He-3 Auction

Notice #14 - October 05, 2012

Dear Colleagues,

The DOE Isotope Program is pleased to announce an upcoming auction for 4,000 liters of He-3 gas.

Please click here for more details.

Please direct any questions regarding this notice to:
Dr. Jehanne Gillo
Director
Facilities and Project Management Division
Office of Nuclear Physics
U.S. Department of Energy
SC-26.2, Germantown Building
1000 Independence Avenue
Washington, D.C. 20585-1290
Email: Jehanne.Gillo@science.doe.gov

Note: after October 9, 2012, more information will also be available on our He-3 auction page.

New Funding Opportunity Announcement

Notice #12 - August 08, 2012

The DOE Office of Science has posted a new Funding Opportunity Announcement in which you may be interested. It is announcement DE-FOA-0000743 – Research, Development and Training in Isotope Production. This competitive opportunity announcement is supported by the Isotope Development and Production for Research and Applications (IDPRA) subprogram in the Office of Nuclear Physics. More information may be found from this PDF file, or by going to the Office of Science Web Site (http://science.energy.gov/), clicking on the tab "Funding Opportunities" near the top center of the page, then selecting "Current Funding Opportunities." Please feel free to distribute this email to interested parties.

A companion announcement has also been made to the National Laboratories, LAB_12-743.

Dr. Jehanne Gillo
Director
Facilities and Project Management Division

Office of Nuclear Physics
U.S. Department of Energy
SC-26.2, Germantown Building
1000 Independence Avenue
Washington, D.C. 20585-1290
email: Jehanne.Gillo@science.doe.gov
phone: (301)-903-1455
fax: (301)-903-3833

Special Notice - Survey Form Private Sector

Notice #09 - March 07, 2012

PLEASE RESPOND DIRECTLY TO WOLFGANG RUNDE AT THE CONTACT INFORMATION PROVIDED BELOW.

This announcement is intended to seek information from private companies on their potential needs of isotopes in the next five years and is not a Request for Proposal (RFP) or an Invitation for Bid (IFB), nor is it to be construed as a commitment by the Government. The Government does not intend to contract on the basis of this request or otherwise pay for any information solicited herein.

The NIDC is requesting that companies complete and submit this survey formto runde@lanl.gov by March 30, 2012. Information should be submitted even if the potential need for an isotope is somewhat uncertain for the coming years. If a specific isotope is not identified or requested by anyone, it may not be considered for production or production development by the IDPRA during fiscal years 2012-2016. For workshop reports and additional information on the IDPRA program, please visit our website at http://science.energy.gov/np/research/idpra.

Private companies who believe that they are in need of isotopes or have identified an isotope supply shortage should contact the point of contact listed in this synopsis. Excluded from this request are Helium-3 and Molybdenum-99.

Primary Point of Contact:
Wolfgang Runde, NIDC
runde@lanl.gov
Phone: (505) 231-0826

MS-Word docx format
PDF format

Message from the NIDC Director - Dr. Robert Atcher

Notice #08 - January 11, 2012

Enriched Water Update

As the market for PET radiopharmaceuticals continues to expand, it appears that a supply pinch has developed. End users reported to me that spot prices have increased on the order of two to three fold over the last year. In conversations with the providers, no apparent shutdown of production capacity appears to have occurred. There is a bottleneck that has developed due to the fact that industry has been hesitant to invest in increased capacity without a clear vision of the future of the demand for F-18 labeled radiopharmaceuticals. There is a sense that the drop in price of enriched water can't be tolerated again and so a very conservative mindset has developed regarding production capacity.

One vendor has told me that they are expanding capacity, but the improvements won't be seen immediately. Thus, there is some expectation that some relief is coming in terms of supply. How this translates to price, either modest decreases or simply stable with time, remains to be seen.

Realize that this information has been generated to answer questions posed by members of the radioisotope user community. The DOE isotope program is not in a position to be able to produce enriched O-18 for the market.

Ac-225 Availability

Notice #07 - October 19, 2011

In conjunction with an ongoing U.S. DOE research collaboration agreement, small quantities (up to 10 mCi) of Ac-225 can be made available for approved research activities on a bi-monthly basis. Please contact the Isotope Business Office at contact@isotopes.gov if you are interested in submitting a request for this material.

Overview of the NIDC

Notice #06 - October 4, 2011

The National Isotope Development Center (NIDC) manages the coordination of isotope production across Department of Energy (DOE) facilities and, for some isotopes, non-Federal facilities as well. The NIDC is supported by the Isotope Development and Production for Research and Applications (IDPRA) Program within the Office of Nuclear Physics of the DOE Office of Science. Part of the NIDC mission is to increase the availability of critical isotopes in short supply. In order for the IDPRA Program to successfully partake in strategic planning to enhance reliability and availability of isotopes to the community, the NIDC seeks information to better understand the demand for isotopes used in research or commercial applications. The information provided in this request form will assist the NIDC to optimize production plans in the upcoming fiscal years and to work with the IDPRA Program to plan strategically the future production of isotopes, gauging future demand, and evaluating the needs for isotope production technology development.

If you have any questions, please contact the Isotope Business Office at (865) 574-6984.

W-188/Re-188 Generator Supply

Notice #05 - September 22, 2011

The DOE Isotope Development and Production for Research and Applications (IDPRA) program has been working to solve a problem with respect to isotope supply. There has been a continuing interest in Re-188 produced from a W-188 generator. That interest needs to be supported to the highest degree possible. At present, we have periodically received requests for that system as well as the W-188 solution.

In an attempt to produce W-188 in the most efficient and economical way possible, we would like to consolidate orders so that we produce batches that are totally obligated, rather than having part of the W-188 produced to decay away without benefiting any customer. In order to accomplish this goal, we need those of you who are interested in using W-188 itself or the W/Re-188 generator, to identify your needs in terms of quantity and frequency and send them to the Isotope Business Office at contact@isotopes.gov with W-188 in the subject line.

We will then work to establish a production schedule that enables us to minimize the number of production runs undertaken while producing the most efficient and economical quality.

If you have any questions, please contact the Isotope Business Office at (865) 574-6984.

Robert W. Atcher, PhD, MBA
Director, National Isotope Development Center
MS T004
Los Alamos National Laboratory
Los Alamos, NM 87545

UNM/LANL Professor of Pharmacy
University of New Mexico

Past President
Society of Nuclear Medicine

NIDC Website Update

Notice #04 - September 9, 2011

We are pleased to announce our updated website at http://isotopes.gov. There are several new, user-friendly tools available on the site including searching for isotopes either by element in the periodic table or by searching the chart of the nuclides. You can now join, change address, or unsubscribe to the NIDC email list, from our website. These tools can be accessed from the QUICK LINKS and BREAKING NEWS tabs. A message will be sent immediately to our Isotope Business Office to address your request.

The changes will continue as we add more content to the site. For those who use isotopes from the program in their research, we would like to add your publications to our bibliography, so please send an electronic copy of the paper as a .pdf and we will include it on the page. We also will try to keep a calendar of upcoming meetings that are relevant for the isotope user community.

Please let us know if there are any comments, complaints or kudos regarding the new website.

Best regards,
Jehanne Gillo

Dr. Jehanne Gillo
Director
Facilities and Project Management Division
Office of Nuclear Physics

email: Jehanne.Gillo@science.doe.gov
U.S. Department of Energy phone: (301)-903-1455
SC-26.2, Germantown Building fax: (301)-903-3833
1000 Independence Avenue
Washington, D.C. 20585-1290

O-18 Workshop

Notice #03 - August 18, 2011

Dear Isotope User:

At the annual Society of Nuclear Medicine meeting, I learned that there have been some changes in the market for enriched O-18 and O-18 labeled water. While I did not get a unanimous sense of changes in the market, it appears that some of the producers have ceased production and the customers are seeing increases in the price of enriched water. In order to explore this issue further, I have asked for a slot of time at the upcoming Society of Radiopharmaceutical Sciences meeting in Amsterdamto have a one hour workshop on this topic. I will send a message later this week with the exact time and location for that meeting, but we have focused on either Monday, 8/29/11, or Tuesday, 8/30/11.

If you have concerns about this issue and will not be attending the SRS meeting, please contact me directly to describe in detail what your concerns are and your experience in securing supplies of enriched water. My email address is ratcher@lanl.gov. If sufficient impact is anticipated, I will try to establish a meeting on this topic that will occur later this calendar year.

Thank you,

Robert Atcher, PhD, MBA
Director
National Isotope Development Center
ratcher@lanl.gov

Isotope Production Solicitation

Notice #02 - May 19, 2011

Dear Colleague,

We are pleased to inform you of a new open solicitation within the Isotope Development and Production for Research and Applications Program. I invite you to consider the request for proposals for isotope production. The Funding Opportunity Announcement can be found at http://science.doe.gov/grants/pdf/SC-FOA-0000517.pdf.

Feel free to contact Dr. Marc Garland with any questions you may have. Please distribute to interested parties. Thank you very much.

Best regards,
Jehanne Gillo

Dr. Jehanne Gillo
Director
Facilities and Project Management Division
Office of Nuclear Physics

email: Jehanne.Gillo@science.doe.gov
U.S. Department of Energy
SC-26.2, Germantown Building
1000 Independence Avenue
Washington, D.C. 20585-1290
phone: (301)-903-1455
fax: (301)-903-3833

Introducing the NIDC Mailing List

Notice #01 - March 24, 2011

Dear Colleague:

We have included you on our new Master Mailing List to receive important notices, news, and future information from the National Isotope Development Center (NIDC).

The Office of Nuclear Physics in the DOE Office of Science supports the Isotope Development and Production for Research and Application program, which produces, processes, and distributes radioactive and stable isotopes that are in short supply and critical to the Nation. The program also supports research and development on the improvement or development of new production and processing techniques for isotopes within the program portfolio. A goal of the program is to make key isotopes more readily available to meet domestic U.S. needs. The NIDC, managed by the Office of Nuclear Physics, is a virtual service organization which interfaces with the user community and manages the coordination of isotope production across facilities, and business operations involved in the production, sale and distribution of isotopes.

If you no longer wish to receive e-mail notices from the NIDC, please reply to:isotope-news at ornl.gov.